Results 151 to 160 of about 349,615 (316)

β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes. [PDF]

Cell Rep, 2019
Lalwani A, Warren J, Liuwantara D, Hawthorne WJ, O'Connell PJ, Gonzalez FJ, Stokes RA, Chen J, Laybutt DR, Craig ME, Swarbrick MM, King C, Gunton JE.   +12 more
europepmc   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Vimentin Overexpressions Induced by Cell Hypoxia Promote Vasculogenic Mimicry by Renal Cell Carcinoma Cells. [PDF]

Biomed Res Int, 2019
Lin H, Hong Y, Huang B, Liu X, Zheng J, Qiu S.   +5 more
europepmc   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis. [PDF]

Front Immunol, 2018
Lin N, Shay JES, Xie H, Lee DSM, Skuli N, Tang Q, Zhou Z, Azzam A, Meng H, Wang H, FitzGerald GA, Simon MC.   +11 more
europepmc   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

Corrigendum: Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells

Frontiers in Bioengineering and Biotechnology, 2022
Carola Schmitz, Ekaterina Potekhina, Teresa Irianto, Vsevolod V. Belousov, Vsevolod V. Belousov, Antonina Lavrentieva   +5 more
openaire   +2 more sources

Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: The pH paradox and cytoprotection by glucose, acidotic pH, and glycine [PDF]

, 1998
Y Nishimura, Lewis H. Romer, John J. Lemasters   +2 more
openalex   +1 more source

Tumor Microenvironment‐responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy

Advanced Healthcare Materials, EarlyView.
An Tumor microenvironment‐responsive nanocatalyst system composed of PLGA‐encapsulated Ca–Fe peroxide and polyarginine enables sustainable Fenton reaction in tumors. Low levels of H2O2 (50–100 µm) initiate the nanoparticle degradation, while polyarginine‐derived nitric oxide accelerates Fe3+ reduction, leading to self‐amplifying •OH generation for ...
Jun Ma, Jingjing Qiu, Shiren Wang
wiley   +1 more source

Pharmacological evidence that the activation of the Na⁺‐Ca²⁺ exchanger protects C6 glioma cells during chemical hypoxia [PDF]

, 1997
Salvatore Amoroso, Matteo De Maio, Giovanni M Russo, Annalisa Catalano, Antonella Bassi, Stefania Montagnani, Gianfranco Di Renzo, Lucio Annunziato   +7 more
openalex   +1 more source