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Hypoxia, Hypoxia-Inducing Factor-1 and Leukemic Cell Differentiation
SCIENTIA SINICA Vitae, 2014Hypoxia-inducible factor-1 (HIF-1), a master transcriptional factor for cellular response to hypoxia, consists of hypoxia-sensitive HIF-1a and constitutively expressed HIF-1b. Studies showed that HIF-1 plays an important role in the progression and metastasis of solid tumors because hypoxia is regarded as a key microenvironment of cancer.
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Hypoxia regulates the hematopoietic stem cell niche
Pflügers Archiv - European Journal of Physiology, 2015Bone marrow, the site of hematopoiesis throughout adulthood, is a physiologically hypoxic organ. Thus, various biological oxygen sensors and their signaling cascades play a pivotal role in hematopoietic systems in the bone marrow under both physiologic and pathologic conditions.
Takayuki, Morikawa, Keiyo, Takubo
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Hypoxia-stabilized RIPK1 promotes cell death
Nature Cell Biology, 2023Wei Ruan +2 more
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Hypoxia and Endothelial Cell Adhesiveness
1995Ischemia is a common clinical event leading to local and remote tissue injury. Reperfusion of the ischemic tissues is associated with a local activation and infiltration of granulocytes (Lucchesi et al., Werns et al). These cells form a potential threat to the function and integrity of the endothelial barrier (Wedmore et al), since they can mediate ...
Anneke Pietersma +3 more
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1996
Abstract : Hypoxia resulting from hemorrhage is a major concern of military medicine, based on studies of mortality and morbidity of battle casualties. In severe hemorrhage or exsanguination, tissues and cells are effectively isolated from the systemic circulation and the response of cells to hypoxia becomes critical.
J. L. Kidwell, T. B. Nielsen
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Abstract : Hypoxia resulting from hemorrhage is a major concern of military medicine, based on studies of mortality and morbidity of battle casualties. In severe hemorrhage or exsanguination, tissues and cells are effectively isolated from the systemic circulation and the response of cells to hypoxia becomes critical.
J. L. Kidwell, T. B. Nielsen
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Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
Nature Reviews Molecular Cell Biology, 2020Pearl Lee +2 more
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Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Signal Transduction and Targeted Therapy, 2022Zhen Luo, Qiwei Zhang, Jianguo Wu
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