Results 271 to 280 of about 349,615 (316)

Pseudohypoxic stabilization of HIF1α via cyclophilin D suppression promotes melanoma metastasis. [PDF]

Signal Transduct Target Ther
Park HK, Hu S, Kim SY, Yoon S, Yoon NG, Lee JH, Choi W, Kong SY, Kim JH, Nam D, Kang BH.   +10 more
europepmc   +1 more source

Biphasic protective effects of macrophage migration inhibitory factor in ischemia/reperfusion-induced acute kidney injury. [PDF]

Commun Biol
Du Y, Feng C, Zhou L, Wang T, Ma H, Liu H.   +5 more
europepmc   +1 more source

DNA-PKcs participates in the repair of renal tubular epithelial cell injury. [PDF]

Ren Fail
Feng D, Hu YJ, Sun L, Zhang J, Niu XL, Huang WY.   +5 more
europepmc   +1 more source

Hypoxia-Modified Cancer Cell Metabolism [PDF]

Frontiers in Cell and Developmental Biology, 2019
While oxygen is critical to the continued existence of complex organisms, extreme levels of oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive levels of oxygen), potentially promote stress within a defined biological environment.
Tina P Dale, Nicholas R Forsyth
exaly   +6 more sources

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Intermittent hypoxia: cell to system

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001
This symposium was organized to present research dealing with the effects of intermittent hypoxia on cardiorespiratory systems and cellular mechanisms. The pattern of neural impulse activity has been shown to be critical in the induction of genes in neuronal cells and involves distinct signaling pathways.
R. Douglas Fields, Tracy L. Baker, Nanduri R. Prabhakar, Eugene C. Fletcher   +3 more
openaire   +2 more sources

Apoptotic Cell Death Under Hypoxia

Physiology, 2014
Eukaryotic life depends largely on molecular oxygen. During evolution, ingenious mechanisms have evolved that allow organisms to adapt when oxygen levels decrease. Many of these adaptional responses to low oxygen are orchestrated by the heterodimeric transcription factor hypoxia-inducible factor (HIF). Here, we review the link between HIF and apoptosis.
Sendoel Ataman, Hengartner Michael O
openaire   +4 more sources

Stem Cells, Hypoxia and Hypoxia-Inducible Factors

2009
Oxygen is a critical environmental factor that regulates the fate of stem cells. In this review, our aims are twofold: (i) to consider the contribution of oxygen tension to the environmental niches in which stem cells and their progeny find themselves and which have a role in determining their fate, and (ii) to define the regulatory networks that ...
Sinead P. Forde, Suzanne M. Watt, Grigorios Tsaknakis, Lee Carpenter   +3 more
openaire   +2 more sources

In vitro intermittent hypoxia: challenges for creating hypoxia in cell culture

Respiratory Physiology & Neurobiology, 2003
Intermittent hypoxia has been implicated in morbidities associated with sleep apnea, and may be a novel cellular signal for inflammation [J. Appl. Physiol. 90 (2001) 1986]. Standard cell culture has two major limitations for studying the effects of steady-state P(O(2)) and intermittent hypoxia.
James E. Baumgardner, Cynthia M. Otto
openaire   +3 more sources

Hypoxia and Lactate Production in Trophoblast Cells

Placenta, 2007
The etiology of preeclampsia is unknown but is thought to be related to hypoxia in the placenta. We previously reported that the enzyme lactate dehydrogenase (LDH) has increased activity and gene expression in placentas from preeclamptic pregnancies [Tsoi SCM, Zheng J, Xu F, Kay HH.
S. Zhu, Stephen Tsoi, Helen H. Kay
openaire   +3 more sources