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Hypoxia-induced autophagy: cell death or cell survival?
Current Opinion in Cell Biology, 2010Hypoxia (approximately 3-0.1% oxygen) is capable of rapidly inducing, via the hypoxia-inducible factor (HIF-1), a cell survival response engaging autophagy. This process is mediated by the atypical BH3-only proteins the Bcl-2/E1B 19kDa-interacting protein 3 (BNIP3/BNIP3L (NIX)) that are induced by HIF-1.
Mazure, N.M., Pouysségur, J.
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Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance
2010Hypoxia promotes tumor progression through multiple mechanisms including modifying angiogenesis, metabolism switch and invasion. Hypoxia inducible factors (HIFs), particularly HIF1α and HIF2α, are key mediators in cancer hypoxia response and high expression levels of HIFs correlate with a poor prognosis in various tumor types. Cancer stem cells (CSCs),
Zhizhong Li, Jeremy N. Rich
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Highlight: sensing hypoxia in the cell and the organism
bchm, 2013No abstract ...
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Hypoxia Tolerance of Coronary Endothelial Cells
1990The coronary endothelium performs a great number of specific metabolic and physiological functions, e.g. the synthesis of autacoids, and the control of the transport of material into and out of the blood stream. For these performances a sufficient supply of metabolic energy is required. Alterations of the energetic state, e.g. due to an insufficient O2
T. Noll +5 more
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Cerebral cell population under hypoxia
The Anatomical Record, 1966AbstractThree pregnant albino Sprague‐Dawley rats were subjected to simulated high altitudes of 18,000 feet (365 mm Hg) in low pressure chambers during their entire pregnancy. The brains of the newborn rats were removed immediately after birth and placed in 10% formalin.
Richard R. Shivers, Paul G. Roofe
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Transcriptional adaptation of neuroblastoma cells to hypoxia
Biochemical and Biophysical Research Communications, 2008Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis.
Sven Påhlman +3 more
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Cell-Autonomous Metabolic Reprogramming in Hypoxia
Trends in Cell Biology, 2018Molecular oxygen (O2) is a universal electron acceptor that enables ATP synthesis through mitochondrial respiration in all metazoans. Consequently, hypoxia (low O2) has arisen as an organizing principle for cellular evolution, metabolism, and (patho)biology, eliciting a remarkable panoply of metabolic adaptations that trigger transcriptional ...
Luana Schito, Sergio Rey
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Hypoxia and Endothelial Cell Adhesiveness
1995Ischemia is a common clinical event leading to local and remote tissue injury. Reperfusion of the ischemic tissues is associated with a local activation and infiltration of granulocytes (Lucchesi et al., Werns et al). These cells form a potential threat to the function and integrity of the endothelial barrier (Wedmore et al), since they can mediate ...
Johan F. Koster +3 more
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Hypoxia in the regulation of neural stem cells
Cellular and Molecular Life Sciences, 2011In aerobic organisms, oxygen is a critical factor in tissue and organ morphogenesis from embryonic development throughout post-natal life, as it regulates various intracellular pathways involved in cellular metabolism, proliferation, survival and fate.
Lidia De Filippis, Domenico Delia
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Sickle cell resistance to in vivo hypoxia
Nature, 1974THE rapid disappearance from circulation of human erythrocytes transfused to rats can be prevented if the animals are pretreated with ethyl palmitate (EP) and a cobra venom factor (CVF)1. The improvement in human erythrocyte survival in these animals is due to EP-induced impairment of reticuloendothelial function2 and to suppression of intravascular ...
Oswaldo Castro +2 more
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