Results 291 to 300 of about 619,300 (360)

Decoding the HIF-1-driven metabolic-inflammatory-immune axis in sepsis-associated lung injury: a comprehensive overview. [PDF]

Front Immunol
Zhang S, Hu B, Fang Y, Liu M, Liu Q, Chen Y, Zhou J.   +6 more
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Healing of ischemic injury in the retina. [PDF]

Sci Adv
Becker S, L'Ecuyer Morison Z, Allen J, Saeid S, Sturgis L, Adderley A, Koskelainen A, Vinberg F.   +7 more
europepmc   +1 more source

Hypoxia-Conditioned Mesenchymal Stem Cells (HC-MSC)-Derived Secretome Gel Induce IL-10 to Improve Diabetic Foot Ulcers via Reduced NF-κB p65 Gene Expression: A Randomized Controlled Trial

Nur Anna Chalimah Sadyah, Heri-Nugroho, Agung Putra, Ignatius Riwanto   +3 more
openalex   +1 more source

Hypoxia in Mesenchymal Stem Cell

, 2017
Widowati, Wahyu, Rihibiha, Dwi Davidson, Khiong, Khie, Widodo, M. Aris, Sumitro, Sutiman B., Bachtiar, Indra   +5 more
openaire   +3 more sources

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Super enhancer-driven LINC01013 mediates hypoxia-induced mitochondrial dysfunction by HSPA9 to determine pulmonary arterial smooth muscle cell fate. [PDF]

Cell Mol Life Sci
Ma C, Wang Z, Zhu X, Pang X, Zhang L, Ou L, Chen Y, Liu Y, Mei J, Guan X, Meng Z, Tang Y, Zhang Z, Li B, Wen S, Shen A, Wang X.   +16 more
europepmc   +1 more source

Transcriptomic and Metabolomic Differential Responses in Hypoxia on RBL-2H3 Cell Through Sodium Cromoglycate Mediates

Rana Hussein Naser
openalex   +2 more sources

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Synergistic Disruption of Survival and Metastatic Potential in Esophageal Adenocarcinoma Cells Through Combined Inhibition of HIF1α and CD73. [PDF]

Cancers (Basel)
Mersich I, Malmberg A, Anik E, Hassan MS, von Holzen U, Blagg BSJ, Ali A.   +6 more
europepmc   +1 more source