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Hypoxia, reactive oxygen, and cell injury
Free Radical Biology and Medicine, 1989Hypoxia usually decreases the formation of reactive oxygen species by oxidases and by autoxidation of components of cellular electron transfer pathways and of quinoid compounds such as menadione. In the case of menadione reactive oxygen species are liberated to a significant extent only at non-physiologically high oxygen partial pressures (PO2).
Littauer A, de Groot H
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Mechanisms of cell survival in hypoxia and hypothermia
Journal of Experimental Biology, 2001SUMMARYMost animals experience some degree of hypoxia and hypothermia during the course of their natural life history either as a consequence of ambient ‘exposure’ per se or through metabolic, respiratory and/or circulatory insufficiency. A prevailing experimental approach has been to probe tissues from natural models of hypoxia-tolerant and cold ...
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1996
Abstract : Hypoxia resulting from hemorrhage is a major concern of military medicine, based on studies of mortality and morbidity of battle casualties. In severe hemorrhage or exsanguination, tissues and cells are effectively isolated from the systemic circulation and the response of cells to hypoxia becomes critical.
J. L. Kidwell, T. B. Nielsen
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Abstract : Hypoxia resulting from hemorrhage is a major concern of military medicine, based on studies of mortality and morbidity of battle casualties. In severe hemorrhage or exsanguination, tissues and cells are effectively isolated from the systemic circulation and the response of cells to hypoxia becomes critical.
J. L. Kidwell, T. B. Nielsen
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Effect of hypoxia on human seminoma cells
International Journal of Oncology, 2002Since hypoxia has been considered to enhance metastatic potential in solid tumors via a neo-angiogenesis caused by vascular endothelial cell growth factors (VEGFs) induced by hypoxia inducible factor-1alpha (HIF-1alpha), the effects of hypoxia on human seminoma cell lines were examined in terms of growth, morphology, gene expression, protein expression
Masaaki Morioka +14 more
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The impact of hypoxia on cell death pathways
Biochemical Society Transactions, 2013Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial infarction, stroke and ischaemic acute kidney injury.
Colin R. Lenihan, Cormac T. Taylor
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Endothelial Cells’ Responses to Hypoxia and Reperfusion
1995Our results suggest that longer periods of hypoxia lead to a deficiency of high energy phosphates. Reoxygenation leads to the formation of ROS, irrespectively of the duration of hypoxia. It might be concluded that a diminished level of intracellular high energy phosphates upon hypoxia followed by oxidative stress plays a key role in the reperfusion ...
Andrea Griesmacher +2 more
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Conquering the Hypoxia Limitation for Photodynamic Therapy
Advanced Materials, 2021Jing Lin, Lian-hua Fu, Peng Huang
exaly
Hypoxia and Visualization of the Stem Cell Niche
2013It is widely accepted that mammalian stem cells reside in a specialized cellular and a cellular microenvironment called the niche. The niche contrary to other tissues is characterized by a low partial Oxygen pressure (ppO2). This microenvironment protects stem cells from deleterious effects of O2 on proteins and DNA, through the production of reactive ...
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Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
Journal of Physiology, 2021Cormac T Taylor, Sarah J Kierans
exaly
Selective Thrombosis of Tumor for Enhanced Hypoxia‐Activated Prodrug Therapy
Advanced Materials, 2021Kai Han, Jin Z Zhang, Mohamed F Foda
exaly