Results 61 to 70 of about 11,093,569 (425)
Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. [PDF]
, 2017 The advent of large-scale in vitro differentiation of human stem cell-derived insulin-producing cells (SCIPC) has brought us closer to treating diabetes using stem cell technology. However, decades of experiences from islet transplantation show that
Faleo, Gaetano +10 more
core +2 more sources
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
Nature Communications, 2019 Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here, we report that genes involved in various human cancers evolved rapidly in Tibetans and six Tibetan domestic mammals compared to reciprocal lowlanders ...
Yulin Shi +20 more
semanticscholar +1 more source
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.
Antioxidants and Redox Signaling, 2017 SIGNIFICANCE Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a disease that currently affects ∼8% of the adult population worldwide.
P. Gerber, G. Rutter
semanticscholar +1 more source
Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence
Cells, 2021 Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment ...
Apostolos Menegakis +9 more
doaj +1 more source
Phenotypic variation modulates the growth dynamics and response to radiotherapy of solid tumours under normoxia and hypoxia [PDF]
arXiv, 2021 In cancer, treatment failure and disease recurrence have been associated with small subpopulations of cancer cells with a stem-like phenotype. In this paper, we develop and investigate a phenotype-structured model of solid tumour growth in which cells are structured by a stemness level, which varies continuously between stem-like and terminally ...
arxiv
Hypoxic regulation of ion channel function and expression [PDF]
, 2002 Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core +1 more source
Journal of Experimental Medicine, 2014 Hypoxia selectively up-regulates PD-L1 on myeloid-derived suppressor cells via HIF-1a, thus affecting T cell activation.
M. Noman +7 more
semanticscholar +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the Fibrillin‐1 gene, which encodes the extracellular matrix protein fibrillin‐1.
Yuhao Chen +12 more
doaj +1 more source
Frontiers in Physiology, 2017 Background : Hypoxia inducible factor 1 alpha (HIF1A) is a master regulator of acute hypoxia; however, with chronic hypoxia, HIF1A levels return to the normoxic levels.
Eugenia Mata-Greenwood +4 more
doaj +1 more source
Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate [PDF]
, 2014 Background Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly derived from glucose. In hypoxia,
Chung, Michelle K. +3 more
core +1 more source