Results 181 to 190 of about 10,955,102 (315)

Flowcytometric Analysis of Tumor Associated Macrophages in Invasive Ductal Carcinoma of Breast [PDF]

Background: Invasive ductal carcinoma is the most common type of breast cancer in Iran. Impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood.
حسن, زهیر محمد, روانگرد, فاطمه, فرازمند, سوسن, امانی, داور, کریم زاده, مجتبی   +4 more
core  

Targeting KRAS Codon 13 Mutations Using Direct Combination Approaches in Non-Small Cell Lung Cancer. [PDF]

Cancer Discov
McDaid WJ, Adderley H, d'Arienzo PD, Parreira AS, Woodhouse LC, Zhuang Y, Castillo-Lluva S, Tinsley KL, Cooksedge J, Baker MJ, Searle J, Brown KD, Carter M, Aldea M, Marinello A, Aredo JV, Gomez Serra N, Bisbe M, East P, de Carné Trécesson S, Barlesi F, Wislez M, Besse B, Wakelee HA, Nadal E, Blackhall F, Wedge DC, Holderfield M, Smith JAM, Singh M, Seamon KJ, Malliri A, Lindsay CR.   +32 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Phytochemical basis and antitumor mechanisms of <i>Psoralea corylifolia</i> L.: implications for tumor immunomodulation and therapeutic development. [PDF]

Front Immunol
Ren Y, Ye P, Cai C, Zhu L, Zhang W, Cao Z, Sun T.   +6 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Cell-Based Assay Development and Standardization for Antibody-Drug Conjugates. [PDF]

BioTech (Basel)
Sun D, Hsu A, Long H, Qin K, Welch J, McCann S, Cheng ZJ.   +6 more
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Comparative DIA Proteomics of Neuroblastoma: Laser-Microdissected FFPE Tumors Versus Cell Lines. [PDF]

Biology (Basel)
Nishimura A, Fujikawa T, Inoue S, Yamamoto N, Yoshida M, Fukuda T, Bando Y, Nozu K, Hasegawa D, Yoshioka A, Sonoda H, Nishimura T, Tamura A.   +12 more
europepmc   +1 more source