Results 121 to 130 of about 5,658,856 (358)

Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

eLife
Air pollution significantly impacts lung cancer progression, but there is a lack of a comprehensive molecular characterization of clinical samples associated with air pollution. Here, we performed a proteogenomic analysis of lung adenocarcinoma (LUAD) in
Honglei Zhang, Chao Liu, Shuting Wang, Qing Wang, Xu Feng, Huawei Jiang, Li Xiao, Chao Luo, Lu Zhang, Fei Hou, Minjun Zhou, Zhiyong Deng, Heng Li, Yong Zhang, Xiaosan Su, Gaofeng Li   +15 more
doaj   +1 more source

Status of ITER neutral beam cell remote handling system

, 2013
The ITER neutral beam cell will contain up to three heating neutral beams and one diagnostic neutral beam, and four upper ports. Though manual maintenance work is envisaged within the cell, when containment is breached, or the radiological protection is ...
Belcher, C, Choi, C-H, Crofts, O, Crowe, R, Damiani, C, Delavalle, S, Meredith, L, Mindham, T, Raimbach, J, Sykes, N, Tesini, A, Van Uffelen, M   +11 more
core   +1 more source

Ganoderma lucidum Polysaccharides Prevent Palmitic Acid-Evoked Apoptosis and Autophagy in Intestinal Porcine Epithelial Cell Line via Restoration of Mitochondrial Function and Regulation of MAPK and AMPK/Akt/mTOR Signaling Pathway [PDF]

, 2019
Zengenni Liang, Zhihang Yuan, Jiajing Guo, Jing Wu, Jine Yi, Jing Deng, Yang Shan   +6 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Cell Line: 2004–2014 [PDF]

Cell, 2014
2014 marks Cell's 40th anniversary, and over the year we have looked back at how discoveries of the last four decades have molded our understanding of biology. The final decade of the Cell Line features a selection of the exceptional scientific work-both landmark papers and essential reviews.
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

CCLHunter: An efficient toolkit for cancer cell line authentication [PDF]

, 2023
Congfan Bu, Xinchang Zheng, Jialin Mai, Zhi Nie, Jingyao Zeng, Qiheng Qian, Tianyi Xu, Yanling Sun, Yīmíng Bào, Jingfa Xiao   +9 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Chromone-Based Copper(II) Complexes as Potential Antitumour Agents: Synthesis, Chemical Characterisation and In Vitro Biological Evaluation

Crystals
Three new complexes of copper(II) and chromone-2-carboxylic acid, a ligand from the group of hydroxypyrones, were synthesised according to the principles of green chemistry.
Nikolina Filipović, Tomislav Balić, Martina Medvidović-Kosanović, Dominik Goman, Berislav Marković, Dalibor Tatar, Sunčica Roca, Katarina Mišković Špoljarić   +7 more
doaj   +1 more source

Characterizing steady states of genome-scale metabolic networks in continuous cell cultures

, 2017
We present a model for continuous cell culture coupling intra-cellular metabolism to extracellular variables describing the state of the bioreactor, taking into account the growth capacity of the cell and the impact of toxic byproduct accumulation.
Fernandez-de-Cossio-Diaz, Jorge, León, Kalet, Mulet, Roberto   +2 more
core   +3 more sources