Results 131 to 140 of about 18,536,823 (334)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Do-it-yourself instrument integration into an existing mammalian cell line development automation platform

SLAS Technology
Laboratory automation in the biopharmaceutical industry as a rule requires contracted service from highly professional automation solution provider, at times involving the purchase and development of specialized or customized hardware and software, which
Jie Ding, Kee Wee Tan, Xiaoyue Chen
doaj  

Predicting Anticancer Drug Responses Using a Dual-Layer Integrated Cell Line-Drug Network Model

PLoS Comput. Biol., 2015
The ability to predict the response of a cancer patient to a therapeutic agent is a major goal in modern oncology that should ultimately lead to personalized treatment.
N. Zhang, Haiyun Wang, Yun Fang, Jun Wang, Xiaoqi Zheng, Xiaole Shirley Liu   +5 more
semanticscholar   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

In Vitro and In Vivo Studies on a Tissue Culture Cell Line Derived from Normal Monkey Heart [PDF]

, 1958
L.L. Coriell, Robert M. McAllister, A. Greene, W. Flagg, Milton G. Tall, Bridget K. Wagner   +5 more
openalex   +1 more source

Caco-2 Cell Line

, 2015
The human epithelial cell line Caco-2 has been widely used as a model of the intestinal epithelial barrier. The Caco-2 cell line is originally derived from a colon carcinoma.
T. Lea
semanticscholar   +1 more source

HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte.

Proceedings of the National Academy of Sciences of the United States of America, 1998
We have derived a cardiac muscle cell line, designated HL-1, from the AT-1 mouse atrial cardiomyocyte tumor lineage. HL-1 cells can be serially passaged, yet they maintain the ability to contract and retain differentiated cardiac morphological ...
W. Claycomb, Nicholas A. Lanson, B. Stallworth, D. B. Egeland, J. Delcarpio, A. Bahinski, N. Izzo   +6 more
semanticscholar   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source

Status of ITER neutral beam cell remote handling system

, 2013
The ITER neutral beam cell will contain up to three heating neutral beams and one diagnostic neutral beam, and four upper ports. Though manual maintenance work is envisaged within the cell, when containment is breached, or the radiological protection is ...
Belcher, C, Choi, C-H, Crofts, O, Crowe, R, Damiani, C, Delavalle, S, Meredith, L, Mindham, T, Raimbach, J, Sykes, N, Tesini, A, Van Uffelen, M   +11 more
core   +1 more source

The cytochrome oxidase defect in ISC‐depleted yeast is caused by impaired iron–sulfur cluster maturation of the mitoribosome assembly factor Rsm22

FEBS Letters, EarlyView.
The yeast mitoribosome assembly factor Rsm22 contains a [4Fe‐4S] cluster that is matured by the mitochondrial iron–sulfur cluster assembly (ISC) machinery. Defects in ISC components result in impaired mitochondrial protein synthesis due to a mitoribosome assembly defect.
Ulrich Mühlenhoff, Dominik Trauth, Weronika Śliwińska, Linda Boss, Roland Lill   +4 more
wiley   +1 more source