Results 151 to 160 of about 18,536,823 (334)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Author Correction: Patient-derived glioblastoma cell lines with conserved genome profiles of the original tissue

Scientific Data, 2023
Soon-Chan Kim, Young-Eun Cho, Young-Kyoung Shin, Hyeon Jong Yu, Tamrin Chowdhury, Sojin Kim, Kyung Sik Yi, Chi-Hoon Choi, Sang-Hoon Cha, Chul-Kee Park, Ja-Lok Ku   +10 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Lateral Line Organ of Fish: A Possible Key to the Hair Cell Problem [PDF]

, 1962
Willem A. van Bergeijk, Gerard G. Harris
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Expression of interleukin 2 receptors on activated human B cells. [PDF]

, 1984
Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated B cells display receptors for IL-2.
Bongiovanni, KF, Depper, JM, Goldman, CK, Greene, WC, Korsmeyer, SJ, Leonard, WJ, Robb, RJ, Sharrow, SO, Waldmann, TA   +8 more
core  

Next-generation characterization of the Cancer Cell Line Encyclopedia

Nature, 2019
M. Ghandi, F. Huang, Judit Jané-Valbuena, G. Kryukov, Christopher C. Lo, E. McDonald, J. Barretina, Ellen T. Gelfand, C. Bielski, Haoxin Li, K. Hu, Alexander Y. Andreev-Drakhlin, Jaegil Kim, J. Hess, B. Haas, F. Aguet, B. Weir, M. Rothberg, B. Paolella, M. Lawrence, Rehan Akbani, Yiling Lu, Hong L. Tiv, P. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, J. Shih, Kevin Hadi, Yanay Rosen, J. Bistline, K. Venkatesan, Anupama Reddy, D. Sonkin, Manway Liu, J. Lehár, Joshua M. Korn, D. Porter, Michael D. Jones, J. Golji, G. Caponigro, Jordan E. Taylor, C. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, A. Kauffmann, Nicolas Stransky, M. Imieliński, Y. Maruvka, A. Cherniack, Aviad Tsherniak, F. Vazquez, Jacob D. Jaffe, A. Lane, D. Weinstock, Cory M. Johannessen, Michael P. Morrissey, F. Stegmeier, R. Schlegel, W. Hahn, G. Getz, G. Mills, J. Boehm, T. Golub, L. Garraway, W. Sellers   +67 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Rubella hemagglutinin prepared in a serial line African green monkey kidney cells [PDF]

, 1968
R R Rafajko, D zur Nedden
openalex   +1 more source