Results 71 to 80 of about 13,311,252 (256)

Cytotoxic effect and IC50 of the candidate formula on MCF-7 cell line, Hela cell line, and HCT116 cell line.

Cytotoxic effect and IC50 of the candidate formula on MCF-7 cell line, Hela cell line, and HCT116 cell line.
Huda Jamal AlMadalli (17952099), Bazigha K. Abdul Rasool (17952102), Francesca Della Sala (4166005), Assunta Borzacchiello (12246284), Naglaa Gamil Shehab (17952105)   +4 more
core   +1 more source

Effects of carvacrol on a human non-small cell lung cancer (NSCLC) cell line, A549 [PDF]

, 2003
15th Annual Meeting of the Japanese-Association-for-Animal-Cell-Technology -- NOV 11-15, 2002 -- Fuchu, JAPANWOS: 000222558600036Carvacrol, the predominant monoterpene in many essential oils of Labitae including Origanum, Satureja, Thymbra, Thymus, and ...
Koparal, Ayşe Tansu, Zeytinoğlu, Melih
core  

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

, 2020
Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating following transplantation and have recently advanced to clinical trials for Parkinson's disease (PD).
Kirik, Deniz,, Kirik, Deniz, Thompson, Lachlan H., Penna, Vanessa,, Hunt, Cameron P.J., de Luzy, Isabelle R.,, Hunt, Cameron P.J.,, Kauhausen, Jessica A., Gantner, Carlos W.,, Bye, Christopher R.,, Thompson, Lachlan H.,, Niclis, Jonathan C.,, Niclis, Jonathan C., Ermine, Charlotte M., Moriarty, Niamh, Bye, Christopher R., Gantner, Carlos W., de Luzy, Isabelle R., Penna, Vanessa, Parish, Clare L., Kauhausen, Jessica A.,, Parish, Clare L.,, Pouton, Colin W., Moriarty, Niamh,, Lund University., Pouton, Colin W.,, Ermine, Charlotte M.,   +26 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Cell proliferation assay for T47D and MDA-MB-231 breast cancer cell line and MCF-10A breast epithelial cell line.

, 2015
Cell proliferation assay for T47D and MDA-MB-231 breast cancer cell line and MCF-10A breast epithelial cell line.
Abdol Hossein Rezaeian (682518), Lei Du-Cuny (682514), Sylvestor Moses (682515), Emmanuelle J. Meuillet (682519), Shuxing Zhang (682520), Hui-Kuan Lin (295008), Zuohe Song (682517), Lu Chen (75170), Sabrina Dumas (682516)   +8 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source