Results 61 to 70 of about 3,159,930 (315)

Isolation and Characterization of Novel Canine Osteosarcoma Cell Lines from Chemotherapy-Naïve Patients

Cells, 2023
The present study aimed to establish novel canine osteosarcoma cell lines (COS3600, COS3600B, COS4074) and characterize the recently described COS4288 cells. The established D-17 cell line served as a reference.
Natascha Leitner, Reinhard Ertl, Simone Gabner, Andrea Fuchs-Baumgartinger, Ingrid Walter, Juraj Hlavaty   +5 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Establishment and characterization of mouse metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma organoids

Scientific Reports
Metabolic dysfunction-associated steatohepatitis (MASH) is a form of chronic liver inflammation associated with metabolic syndrome, such as obesity and a major cause of hepatocellular carcinoma (HCC).
Sumin Kim, Nahyun Jeong, Jeayeon Park, Hyojin Noh, Ja Oh Lee, Su Jong Yu, Ja-Lok Ku   +6 more
doaj   +1 more source

Effective Targeted Gene Knockdown in Mammalian Cells Using the piggyBac Transposase-based Delivery System

Molecular Therapy: Nucleic Acids, 2013
Nonviral gene delivery systems are rapidly becoming a desirable and applicable method to overexpress genes in various types of cells. We have recently developed a piggyBac transposase-based, helper-independent and self-inactivating delivery system ...
Jesse B Owens, Juanita Mathews, Philip Davy, Ilko Stoytchev, Stefan Moisyadi, Rich Allsopp   +5 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

A machine vision-based in situ probe for automated on-line measurement of cell density and viability by dark field microscopy, image processing and pattern recognition [PDF]

, 2007
Wei N. A machine vision-based in situ probe for automated on-line measurement of cell density and viability by dark field microscopy, image processing and pattern recognition.
Wei, Ning
core   +1 more source

Establishment of pluripotent cell lines from vertebrate species - Present status and future prospects [PDF]

, 1999
Pluripotent embryonic stem (ES) cells are undifferentiated cell lines derived from early embryos and are capable of unlimited undifferentiated proliferation in vitro.
Vassilieva, Svetlana G., Wobus, Anna M., Wolf, Eckhard, Prelle, Katja, Vassiliev, Ivan M.   +4 more
core   +1 more source

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease [PDF]

, 2020
Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating following transplantation and have recently advanced to clinical trials for Parkinson's disease (PD).
Kirik, Deniz,, Kirik, Deniz, Thompson, Lachlan H., Penna, Vanessa,, Hunt, Cameron P.J., de Luzy, Isabelle R.,, Hunt, Cameron P.J.,, Kauhausen, Jessica A., Gantner, Carlos W.,, Bye, Christopher R.,, Thompson, Lachlan H.,, Niclis, Jonathan C.,, Niclis, Jonathan C., Ermine, Charlotte M., Moriarty, Niamh, Bye, Christopher R., Gantner, Carlos W., de Luzy, Isabelle R., Penna, Vanessa, Parish, Clare L., Kauhausen, Jessica A.,, Parish, Clare L.,, Pouton, Colin W., Moriarty, Niamh,, Lund University., Pouton, Colin W.,, Ermine, Charlotte M.,   +26 more
core   +1 more source

Effects of simulated microgravity on colorectal cancer organoids growth and drug response

Scientific Reports
Cellular and molecular dynamics of human cells are constantly affected by gravity. Alteration of the gravitational force disturbs the cellular equilibrium, which might modify physiological and molecular characteristics. Nevertheless, biological responses
Soon-Chan Kim, Min Jung Kim, Ji Won Park, Young-Kyoung Shin, Seung-Yong Jeong, Sungwan Kim, Ja-Lok Ku   +6 more
doaj   +1 more source

ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis

mAbs
N-glycosylation, a critical quality attribute of monoclonal antibodies, plays a pivotal role in regulating pharmacokinetics and pharmacodynamics through high-mannose (Man5) glycoform modulation.
Ruiqiang Sun, Miaomiao Chai, Jiahao Man, Guiju Yang, Hai Shu, Qiancheng Wang, Cong Tian, Linlin Wang, Shanhui Liao, Yifeng Zhang, Yanyan Cao, Lisha Xia, Haili Yang, Ting Zhang, Luoyan Ma, Shenwang Cao, Qiao Gao, Yichen Le, Mingli Shi, Quanxue Li, Yinmao Fan, Hang Zhou   +21 more
doaj   +1 more source