Results 1 to 10 of about 2,579,673 (269)

Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation

Nature Communications, 2016
It is unclear how the cytoskeleton acts to assist in TGF-β signalling downstream of the receptor. Here, in zebrafish, the authors show that the actin-bundling protein FSCN1 interacts with TGF-β type I receptors ALK 4 and 5, enabling actin filament ...
Zhaoting Liu, Guozhu Ning, Ranran Xu, Yu Cao, Anming Meng, Qiang Wang   +5 more
doaj   +1 more source

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

Frontiers in Immunology, 2018
S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which palmitoyl chain is attached to a cysteine residue via a thioester linkage.
Justyna Sobocińska, Paula Roszczenko-Jasińska, Anna Ciesielska, Katarzyna Kwiatkowska   +3 more
doaj   +1 more source

X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB

Communications Biology, 2021
Guan and Hariharan report two crystal structures of melibiose transporter MelB in complex with substrate analogs, nitrophenyl-galactoside, and dodecyl-melibioside.
Lan Guan, Parameswaran Hariharan
doaj   +1 more source

TTL-Expression Modulates Epithelial Morphogenesis

Frontiers in Cell and Developmental Biology, 2021
Epithelial monolayer formation depends on the architecture and composition of the microtubule cytoskeleton. Microtubules control bidirectional trafficking and determine the positioning of structural cellular proteins.
Manuel Müller, Manuel Müller, Karina Ringer, Karina Ringer, Florian Hub, Natalia Kamm, Thomas Worzfeld, Thomas Worzfeld, Thomas Worzfeld, Ralf Jacob, Ralf Jacob   +10 more
doaj   +1 more source

M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole

Nature Communications, 2018
Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al.
Ning Huang, Donghui Zhang, Fangyuan Li, Peiyuan Chai, Song Wang, Junlin Teng, Jianguo Chen   +6 more
doaj   +1 more source

Cell membranes resist flow [PDF]

Cell, 2018
SUMMARY The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds. This conjectured signaling mechanism has been invoked to explain how cells coordinate changes in shape,
Shi, Zheng, Graber, Zachary T., Baumgart, Tobias, Stone, Howard A., Cohen, Adam E.   +4 more
openaire   +2 more sources

Cytokinetic abscission requires actin-dependent microtubule severing

Nature Communications
Cell division is completed by the abscission of the intercellular bridge connecting the daughter cells. Abscission requires the polymerization of an ESCRT-III cone close to the midbody to both recruit the microtubule severing enzyme spastin and scission ...
Tamara Advedissian, Stéphane Frémont, Arnaud Echard   +2 more
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ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export

Nature Communications
The determinants of sub-cellular trafficking for many membrane proteins are poorly understood. Lipid-driven membrane nanodomains known as lipid rafts have been widely implicated in post-Golgi traffic, but their involvement in protein sorting in the ...
Ivan Castello-Serrano, Shikha Dagar, Rossana Ippolito, Kandice R. Levental, Ilya Levental   +4 more
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Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria

Molecules, 2017
In addition to gap junctional channels that mediate cell-to-cell communication, connexins form hemichannels that are present at the plasma membrane. Since hemichannels are permeable to small hydrophilic compounds, including metabolites and signaling ...
Mariana C. Fiori, Srinivasan Krishnan, Abbey Kjellgren, Luis G. Cuello, Guillermo A. Altenberg   +4 more
doaj   +1 more source

Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains

Frontiers in Microbiology, 2017
The overexpression of RND-type exporters is one of the main causes of multidrug resistance (MDR) in Gram-negative pathogens. In RND transporters, such as Escherichia coli's main efflux pump AcrB, drug efflux occurs in the porter domain, while protons ...
Martijn Zwama, Martijn Zwama, Martijn Zwama, Katsuhiko Hayashi, Katsuhiko Hayashi, Keisuke Sakurai, Ryosuke Nakashima, Kimie Kitagawa, Kunihiko Nishino, Akihito Yamaguchi   +9 more
doaj   +1 more source