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3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function

open access: yesAdvanced Biology, EarlyView.
This study reveals that the physical environment surrounding muscle stem cells (MuSCs) plays a crucial role in their function. Using a 3D hydrogel system, it shows that increased confinement preserves MuSC stemness by limiting activation, proliferation, and differentiation.
GaYoung Park   +3 more
wiley   +1 more source

The Aging Substantia Nigra is Characterized by ROS Accumulation Potentially Resulting in Increased Neuroinflammation and Cytoskeletal Remodeling

open access: yesAdvanced Biology, EarlyView.
Definition of study groups, including young individuals (n = 7 mean age: 28.7 years), middle aged individuals (n = 14 mean age: 62.3 years) and elderly individuals (n = 14 mean age: 83.9 years). Condensed workflow including sample preparation (sample lysis and tryptic digestion), mass spectrometric measurements and subsequent data and statistical ...
Britta Eggers   +10 more
wiley   +1 more source

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