Results 51 to 60 of about 3,918,856 (298)

NPC1-dependent alterations in KV2.1–CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease

open access: yesNature Communications, 2023
Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferred to the ER ...
Maria Casas   +7 more
doaj   +1 more source

Oxygen reduction at the silver/hydroxide-exchange membrane interface [PDF]

open access: yes, 2008
A solid-state cell is used to study the electrocatalysis of oxygen reduction at the silver/hydroxide-exchange membrane interface. The catalyst/membrane interface exhibits improved performance in comparison to a catalyst/aqueous sodium hydroxide interface.
Abd El Rehim   +22 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Fabrication of PEM Fuel Cell Bipolar Plates by Indirect SLS [PDF]

open access: yes, 2004
The paper presents a new manufacturing technique involving Selective Laser Sintering (SLS) for proton exchange membrane fuel cell (PEMFC) bipolar plate fabrication.
Bourell, David L.   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

open access: yesNature Communications, 2018
Multidrug transporters possess several drug binding sites. Here the authors describe a transport path specific for planar aromatic cations in the E. coli multi-drug transporter AcrB.
Martijn Zwama   +5 more
doaj   +1 more source

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

open access: yesFrontiers in Immunology, 2018
S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which palmitoyl chain is attached to a cysteine residue via a thioester linkage.
Justyna Sobocińska   +3 more
doaj   +1 more source

X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB

open access: yesCommunications Biology, 2021
Guan and Hariharan report two crystal structures of melibiose transporter MelB in complex with substrate analogs, nitrophenyl-galactoside, and dodecyl-melibioside.
Lan Guan, Parameswaran Hariharan
doaj   +1 more source

TTL-Expression Modulates Epithelial Morphogenesis

open access: yesFrontiers in Cell and Developmental Biology, 2021
Epithelial monolayer formation depends on the architecture and composition of the microtubule cytoskeleton. Microtubules control bidirectional trafficking and determine the positioning of structural cellular proteins.
Manuel Müller   +10 more
doaj   +1 more source

Cytotoxicity of the Bacillus thuringiensis Crystal Protein against Mammalian Cells [PDF]

open access: yes, 2002
The crystal proteins produced by Bacillus thuringiensis subsp, israelensis (Bti) and subsp. coreanensis A1519 strain were examined for the cytotoxicity against MOLT-4 and HeLa cells by MTT assay and LDH assay, The A1519 crystal proteins processed by ...
Akao, Tetsuyuki   +5 more
core   +1 more source

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