Results 61 to 70 of about 3,387,066 (378)

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

Frontiers in Immunology, 2018
S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which palmitoyl chain is attached to a cysteine residue via a thioester linkage.
Justyna Sobocińska, Paula Roszczenko-Jasińska, Anna Ciesielska, Katarzyna Kwiatkowska   +3 more
doaj   +1 more source

Discovery of the Potentiator of the Pore-Forming Ability of Lantibiotic Nisin: Perspectives for Anticancer Therapy

Membranes, 2022
This study was focused on the action of lantibiotic nisin on the phospholipid membranes. Nisin did not produce ion-permeable pores in the membranes composed of DOPC or DOPE. The introduction of DOPS into bilayer lipid composition led to a decrease in the
Dayana N. Chernyshova, Alexander A. Tyulin, Olga S. Ostroumova, Svetlana S. Efimova   +3 more
doaj   +1 more source

The stochastic entry of enveloped viruses: Fusion vs. endocytosis [PDF]

, 2007
Viral infection requires the binding of receptors on the target cell membrane to glycoproteins, or ``spikes,'' on the viral membrane. The initial entry is usually classified as fusogenic or endocytotic.
Barocchi, Chaipan, Cross, Deserno, Diaz-Griffero, Dimitrov, Duzgunes, D’Orsogna, Geijtenbeek, Henderson, Kuhmann, Lai, Lakadamyali, Leikina, Markosyan, Marsh, Masaki, Melikyan, Melikyan, Mothes, Platt, Praefcke, Schaeffer, Shekel, Su, Tom Chou, Tumpey, Yoon, Zhu   +28 more
core   +2 more sources

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

Nature Communications, 2018
Multidrug transporters possess several drug binding sites. Here the authors describe a transport path specific for planar aromatic cations in the E. coli multi-drug transporter AcrB.
Martijn Zwama, Seiji Yamasaki, Ryosuke Nakashima, Keisuke Sakurai, Kunihiko Nishino, Akihito Yamaguchi   +5 more
doaj   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells

Frontiers in Cardiovascular Medicine, 2022
The senescence of cardiovascular endothelial cells (ECs) is a major risk factor in the development of aging-related cardiovascular diseases. However, the molecular dynamics in cardiovascular EC aging are poorly understood.
Bo Gou, Bo Gou, Bo Gou, Bo Gou, Xiaojing Chu, Xiaojing Chu, Xiaojing Chu, Yi Xiao, Yi Xiao, Yi Xiao, Yi Xiao, Pinxuan Liu, Pinxuan Liu, Pinxuan Liu, Pinxuan Liu, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang, Zeyu Gao, Zeyu Gao, Zeyu Gao, Moshi Song, Moshi Song, Moshi Song, Moshi Song   +25 more
doaj   +1 more source

Membrane tension feedback on shape and motility of eukaryotic cells [PDF]

, 2015
In the framework of a phase field model of a single cell crawling on a substrate, we investigate how the properties of the cell membrane affect the shape and motility of the cell. Since the membrane influences the cell dynamics on multiple levels and provides a nontrivial feedback, we consider the following fundamental interactions: (i) the reduction ...
arxiv   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation

Nature Communications, 2016
It is unclear how the cytoskeleton acts to assist in TGF-β signalling downstream of the receptor. Here, in zebrafish, the authors show that the actin-bundling protein FSCN1 interacts with TGF-β type I receptors ALK 4 and 5, enabling actin filament ...
Zhaoting Liu, Guozhu Ning, Ranran Xu, Yu Cao, Anming Meng, Qiang Wang   +5 more
doaj   +1 more source