Results 51 to 60 of about 2,877,371 (319)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis [PDF]
, 2009 The final step during cell division is the separation of daughter cells, a process that requires the coordinated delivery and assembly of new membrane to the cleavage furrow.
Manuel Rauch +31 more
core +1 more source
Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition
Nature Communications, 2018 Multidrug transporters possess several drug binding sites. Here the authors describe a transport path specific for planar aromatic cations in the E. coli multi-drug transporter AcrB.
Martijn Zwama +5 more
doaj +1 more source
Protein Palmitoylation and Its Role in Bacterial and Viral Infections
Frontiers in Immunology, 2018 S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which palmitoyl chain is attached to a cysteine residue via a thioester linkage.
Justyna Sobocińska +3 more
doaj +1 more source
Cell membranes resist flow [PDF]
Cell, 2018 SUMMARY The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds. This conjectured signaling mechanism has been invoked to explain how cells coordinate changes in shape,
Shi, Zheng +4 more
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis
, 2007 Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Periasamy Selvaraj +2 more
core +1 more source
Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation
Nature Communications, 2016 It is unclear how the cytoskeleton acts to assist in TGF-β signalling downstream of the receptor. Here, in zebrafish, the authors show that the actin-bundling protein FSCN1 interacts with TGF-β type I receptors ALK 4 and 5, enabling actin filament ...
Zhaoting Liu +5 more
doaj +1 more source
Communications Biology, 2021 Guan and Hariharan report two crystal structures of melibiose transporter MelB in complex with substrate analogs, nitrophenyl-galactoside, and dodecyl-melibioside.
Lan Guan, Parameswaran Hariharan
doaj +1 more source
TTL-Expression Modulates Epithelial Morphogenesis
Frontiers in Cell and Developmental Biology, 2021 Epithelial monolayer formation depends on the architecture and composition of the microtubule cytoskeleton. Microtubules control bidirectional trafficking and determine the positioning of structural cellular proteins.
Manuel Müller +10 more
doaj +1 more source