Results 131 to 140 of about 377,298 (310)

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

The origin ofhigh hydraulic resistance for filter cakes ofdef ormable particles: cell-bed deformation or surface-layer effect? [PDF]

, 2004
This study reports a numerical approach for modeling the hydraulic resistance ofa filter cake ofdef ormable cells. First, a mechanical and osmotic model that describes the volume fraction ofsolids in a bed ofyeast cells as a function ofthe compressive ...
Molle, Catherine, Clifton, Michael J., Molle, C, Aimar, Pierre, Clifton, Michaël, Meireles, Martine   +5 more
core   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Basic examination of the cell membrane permeability of site probe agents using a cell membrane plate

, 2009
P(論文)Drug efficacy depends on the amount of a preparation reaching the target tissue (grade of tissue transfer). In this experiment, we established the normal albumin concentration of a healthy adult (600 μ M) or a low-albumin state indicating marked ...
7000, 7002, KAWAI, Keiichi, オガタ, ケンジ, ニシオ, トヨタカ, 1021, 9000006346074, 1020, 7161, 徳永, 仁, 1338, 1019, 9000006682222, 1014, 1013, 1012, カワイ, ケイイチ, Tokunaga, Jin, 緒方, 賢次, 高村, 徳人, 西尾, 豊隆, ヨシダ, ヒロキ, 1348, 1000020369169, 1347, 1028, YOSHIDA, Hiroki, 1027, 1026, KONDO, Teruyoshi, 7008, 9000004722867, 川井, 恵一, 7007, NAGATA, Masashi, 20369169, 1000030204663, 近藤, 照義, 9000002747927, 吉田, 裕樹, 90469411, 60369171, Takamura, Norito, 9000002747765, Ogata, Kenji, 1357, 9000002747919, 1758, 9000006242775, 7156, 7155, 1000060369171, トクナガ, ジン, ナガタ, マサシ, 永田, 将司, 1000090509580, NISHIO, Toyotaka, 1766, タカムラ, ノリト, 1762, コンドウ, テルヨシ, 90509580, 1000090469411, 5925   +63 more
core   +1 more source

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Poor Membrane Permeability Ability of SANT75 across Caco-2 Cell Monolayer Due to high Cellular Accumulation

, 2010
BACKGROUND. SANT75(Smoothened antagonist 75) has been identified and characterized as Smo inhibitor by screening from a small molecule library designed based on the scaffold of Smo agonist SAG[1].
李娜, 于洋, 胡莹, 杨凌, 李松, 车超   +5 more
core  

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

The effect of changes in plasma membrane lipid composition on the heat sensitivity of Hepatoma tissue culture cells and selected plasma membrane enzymes [PDF]

, 1990
Hepatoma Tissue Culture (HTC) cells grown in the presence of 60µM arachidonic acid for 24, 36 and 48 hours became progressively more thermosensitive than control cells.
Ladha, S, Ladha, Shabirali
core