Results 211 to 220 of about 634,463 (257)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

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SIMULATION OF CELL MOVEMENT AND INTERACTION

Journal of Bioinformatics and Computational Biology, 2011
A mechanical model of cell motion was developed that reproduced the behaviour of cells in 2-dimensional culture. Cell adhesion was modelled with inter-cellular cross-links that attached for different times giving a range of adhesion strength. Simulations revealed an adhesion threshold below which cell motion was almost unaffected and above which cells
William R. Taylor, Zoe Katsimitsoulia, Alexei Poliakov   +2 more
openaire   +2 more sources

Nuclear movement in multinucleated cells

Development, 2022
ABSTRACTNuclear movement is crucial for the development of many cell types and organisms. Nuclear movement is highly conserved, indicating its necessity for cellular function and development. In addition to mononucleated cells, there are several examples of cells in which multiple nuclei exist within a shared cytoplasm.
Jorel R. Padilla, Lillie M. Ferreira, Eric S. Folker   +2 more
openaire   +2 more sources

Effects of brefeldin A on the localization of Tobamovirus movement protein and cell-to-cell movement of the virus

Virology, 2007
It has been demonstrated that the subcellular location of Tobamovirus movement protein (MP) which was fused with green fluorescent protein (MP:GFP) changed during the infection process. However, the intracellular route through which MP is transported and its biological meaning are still obscure.
Yuichiro Watanabe
exaly   +3 more sources

Cell-to-cell movement of plant viruses

Trends in Microbiology, 1993
To establish an infection, most plant viruses move from cell to cell in the plant. Virus-encoded movement proteins mediate this process and appear to use two mechanisms for transport. Both mechanisms involve interaction with and potential modification of plant intercellular connections, the plasmodesmata.
B G, McLean, E, Waigmann, V, Citovsky, P, Zambryski   +3 more
openaire   +2 more sources

Movement Profiles: A Tool for Quantitative Analysis of Cell-to-Cell Movement of Plant Viral Movement Proteins

2008
Movement proteins (MPs) are virally encoded factors that mediate transport of viral nucleic acid between plant cells. Many MPs are able to move between cells themselves. This feature serves as the basis for evaluation of the transport activity of individual MPs.
Kateryna, Trutnyeva, Pia, Ruggenthaler, Elisabeth, Waigmann   +2 more
openaire   +2 more sources

Cell Movement and Cell Behaviour

Journal of Cell Science, 1987
ABSTRACT John Lackie’s course on cell behaviour delivered to Senior Honours Cell Biology students at Glasgow University is largely responsible for the predominance of young Glaswegian scientists at British conferences on cell behaviour.
openaire   +1 more source

Cyclic GMP and Cell Movement

Nature, 1973
THE movement of mammalian cells can be inhibited by agents which mimic or produce increases in the intracellular levels of cyclic 3′,5′-adenosine monophosphate (cyclic AMP)1,2. Goldberg and coworkers3,4 have proposed that in a number of cell types cyclic 3′,5′-guanosine monophosphate (cyclic GMP) promotes cellular events that are antagonistic to those ...
R D, Estensen, H R, Hill, P G, Quie, N, Gogan, N D, Goldberg   +4 more
openaire   +2 more sources

Kinesin Assembly and Movement in Cells

Annual Review of Biophysics, 2011
Long-distance transport in eukaryotic cells is driven by molecular motors that move along microtubule tracks. Molecular motors of the kinesin superfamily contain a kinesin motor domain attached to family-specific sequences for cargo binding, regulation, and oligomerization.
Kristen J, Verhey, Neha, Kaul, Virupakshi, Soppina   +2 more
openaire   +2 more sources