Results 151 to 160 of about 7,279,295 (308)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Senescent Fibroblasts Impair B Cell Proliferation via Cell-Cell Contact. [PDF]

Aging Cell
Vezyrgianni K, MacLeod E, Nutley A, Zhu Y, Denton AE.   +4 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines. [PDF]

Mol Med Rep
Zhang S, Zhou Y, Zha Y, Yang Y, Wang L, Li J, Jin W.   +6 more
europepmc   +1 more source

miR-101 regulates cell proliferation and apoptosis by targeting KDM1A in diffuse large B cell lymphoma

, 2019
Yiqun Huang, Yong Zou, Luhui Lin, Xudong Ma, Ruiji Zheng Department of Hematology, Zhangzhou Affiliated Hospital of Fujian Medical University, 363000 Zhangzhou, People’s Republic of China Background: miR-101 is reported to be associated with cell ...
Zou Y, Huang Y, Ma X, Zheng R, Lin L
core  

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

PAK4-targeting PROTAC inhibits bladder cancer cell proliferation. [PDF]

PLoS One
Xu S, Xie H, Yang Z, Ma Z, Bai X, Feng X, An J, Ma B.   +7 more
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

H3K18 Lactylation Promotes Cell Proliferation in T-Cell Acute Lymphoblastic Leukemia. [PDF]

J Cell Biochem
Feng L, Jin X, Zhang J, Zhai Z, Zhang X, Wang Y.   +5 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source