Results 231 to 240 of about 15,022,196 (353)

TRPM7 kinase regulates α-cell proliferation and glucagon production in mice. [PDF]

Mol Metab
Boulassel S, Schreier PCF, Beck A, Choi H, Melyshi AM, Reinach PS, Duraj M, Vinogradov M, Suleimen B, Berger J, Jacob K, Breit A, Zierler S, Boekhoff I, Gudermann T, Khajavi N.   +15 more
europepmc   +1 more source

Role of AhR in positive regulation of cell proliferation and survival

Cell Proliferation, 2016
Jiuheng Yin, B. Sheng, Y. Qiu, Kunqiu Yang, W. Xiao, Hua Yang   +5 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Kynurenine promotes porcine intestinal epithelial cell proliferation by activating the AHR-MST1-YAP1 axis. [PDF]

J Anim Sci Biotechnol
Hu Z, Yin L, Wang Q, Deng J, Zhu X, Yang H, Zhang P, Yin Y, Tang X.   +8 more
europepmc   +1 more source

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

Development, 2016
Jason S. L. Yu, W. Cui
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

MAFB regulates hematopoietic stem cell proliferation and maintenance. [PDF]

Sci Rep
Asano S, Liao CW, Matsunaga Y, Jeon H, Sawaguchi K, Asano K, Kusakabe M, Shahri ZJ, Gogoleva N, Yokomizo T, Takahashi S, Hamada M.   +11 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Rab5 nucleotide binding promotes oxidative metabolism to fuel hepatocellular carcinoma cell proliferation. [PDF]

J Biol Chem
Otakhor KO, Zaidi MAA, Oberley-Deegan RE, Ponnusamy MP, Fisher KW, Schott MB.   +5 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source