Results 81 to 90 of about 7,279,295 (308)

An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus

Molecules, 2015
Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene ...
Zizhen Liang, Tiantian Zhang, Xiaoqian Zhang, Jia Zhang, Changqi Zhao   +4 more
doaj   +1 more source

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist   +19 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Interaction Between Malat1 and miR-499-5p Regulates Meis1 Expression and Function with a Net Impact on Cell Proliferation

Meis1 is a transcription factor involved in numerous functions including development and proliferation and has been previously shown to harness cell cycle progression. In this study, we used in silico analysis to predict that miR-499-5p targets Meis1 and
Sameh Magdeldin, Injie Omar Fawzy, Salma A. Fahim, Rana Metwale, Aya Osama, Shereen Ahmed El Sobky, Hesham A. Sadek, Ahmed Karam, Ahmed Ihab Abdelaziz, Manon Ragheb, Mohamed Dief Allah Abdalmoneam Elsayed, Ahmed Abdellatif, Nada El-Ekiaby, Ibrahim Hassan Fayed   +13 more
core   +1 more source

TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation

, 2021
Cell proliferation and differentiation require signaling pathways that enforce appropriate and timely gene expression. We find that Tor2, the catalytic subunit of the TORC1 complex in fission yeast, targets a conserved nuclear RNA elimination network ...
Zofall, Martin, Pan, Lixia, Dhakshnamoorthy, Jothy, Lee, Nathan, Grewal, Shiv, Wei, Yi, Wheeler, David, David Wheeler, Nathan N. Lee, Martin Zofall, Ling-Ling Sun, Lee, Nathan N., Grewal, Shiv I. S., Shiv I. S. Grewal, Sun, Ling-Ling, Lixia Pan, Yi Wei, Jothy Dhakshnamoorthy   +17 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury [PDF]

, 2006
Neuregulin/erbB signaling is critically required for survival and proliferation of Schwann cells as well as for establishing correct myelin thickness of peripheral nerves during development.
Atanasoski, Suzana, Birchmeier, C., Garratt, Alistair N., Birchmeier, Carmen, Suter, U., Sirkowski, E., Scherer, Steven S., Atanasoski, S., Suter, Ueli, Scherer, S.S., Sirkowski, Erich, Garratt, A.N., S. Atanasoski, Leone, Dino, Leone, D., Atanasoski S, Birchmeier C, Suter U, Scherer SS, Garratt AN, Leone D, Sirkowski E   +21 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

ß1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli [PDF]

, 2005
Integrins are cell adhesion receptors which mediate interactions between the extracellular matrix and the actin cytoskeleton. They are heterodimers composed of α and β subunits. As adhesion receptors, integrins are important for cell-cell and cell-matrix
Li, Na
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source