Results 61 to 70 of about 15,022,196 (353)

The role of recombinant epidermal growth factor and serotonin in the stimulation of tumor growth in a SCCHN xenograft model [PDF]

, 2012
One challenge of squamous cell carcinoma of the head and neck (SCCHN) chemotherapy is a small percentage of tumor cells that arrest in the G0 phase of the cell cycle and are thus not affected by chemotherapy. This could be one reason for tumor recurrence
Arnoldner, Christoph, Diensthuber, Marc, Eckardt, Anne Gisela, Geißler, Christin, Hambek, Markus, Stöver, Timo, Wagenblast, Jens   +6 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of langerhans [PDF]

, 2008
Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Burns, Christopher, Jones, Peter, Kitsou-Mylona, Isidora, Persaud, Shanta, Squires, Paul   +4 more
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

The Expression Regulation and Biological Function of Autotaxin

Cells, 2021
Autotaxin (ATX) is a secreted glycoprotein and functions as a key enzyme to produce extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled receptors, LPAR1-6, on the cell membrane to activate various signal ...
Xiaotian Zhang, Mengmiao Li, Nan Yin, Junjie Zhang   +3 more
doaj   +1 more source

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors

Nature Cell Biology, 2018
As oxygen is essential for many metabolic pathways, tumour hypoxia may impair cancer cell proliferation1–4. However, the limiting metabolites for proliferation under hypoxia and in tumours are unknown.
J. Garcia-Bermudez, Lou Baudrier, Konnor C. La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O. Sviderskiy, T. Papagiannakopoulos, H. Molina, M. Snuderl, C. Lewis, Richard L. Possemato, Kıvanç Birsoy   +11 more
semanticscholar   +1 more source

Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. [PDF]

, 2008
ObjectiveThe aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass.Research design and methodsWe analyzed the capacity of beta-cell expansion in 1.5- and 8-month-old mice in response to a high-fat ...
Bhushan, Anil, Dhawan, Sangeeta, Gurlo, Tatyana, Tschen, Shuen-Ing   +3 more
core   +1 more source

Probabilistic approach to a proliferation and migration dichotomy in the tumor cell invasion

, 2008
The proliferation and migration dichotomy of the tumor cell invasion is examined within a two-component continuous time random walk (CTRW) model.
Fedotov, Sergei, Iomin, Alexander
core   +1 more source

Genome-wide analysis of gene expression profiles associated with cell cycle transitions in growing organs of Arabidopsis [PDF]

, 2005
Organ growth results from the progression of component cells through subsequent phases of proliferation and expansion before reaching maturity. We combined kinematic analysis, flowcytometry, and microarray analysis to characterize cell cycle regulation ...
Beemster, Gerrit, De Veylder, Lieven, Vercruysse, Steven, West, Gerrit, Rombaut, Debbie, Van Hummelen, Paul, Galichet, Arnaud, Gruissem, Wilhelm, Inzé, Dirk, Vuylsteke, Marnik   +9 more
core   +2 more sources

Dendritic cell MST1 inhibits Th17 differentiation

Nature Communications, 2017
The differentiation of Th17 cells is central to infection and autoimmunity. Here, the authors show that expression of MST1 by dendritic cells limits IL-6 production and thereby controls Th17 differentiation in immunity to fungal infection and ...
Chunxiao Li, Yujing Bi, Yan Li, Hui Yang, Qing Yu, Jian Wang, Yu Wang, Huilin Su, Anna Jia, Ying Hu, Linian Han, Jiangyuan Zhang, Simin Li, Wufan Tao, Guangwei Liu   +14 more
doaj   +1 more source