Results 61 to 70 of about 19,324,791 (349)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

eLife
Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study,
Wencong Lyu, Haochen Wang, Zhehao Du, Ran Wei, Jianuo He, Fanju Meng, Jinlong Bi, Lijun Zhang, Chao Zhang, Yiting Guan, Wei Tao   +10 more
doaj   +1 more source

Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis

Cells, 2022
Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver disease and two of the most prevalent forms of chronic liver disease.
Sandra Torres, Paula Segalés, Carmen García-Ruiz, José C. Fernández-Checa   +3 more
doaj   +1 more source

Generation of somatic cell hybrids for the production of biologically active factors that stimulate proliferation of other cells

, 2007
Objective: Some normal somatic cells in culture divide a limited number of times before entering a non-dividing state called replicative senescence and fusion of normal cells with immortal cells claimed to produce hybrid cells of limited proliferation ...
Panduri, V, Islam, Khaleda,, Islam, Quamrul,   +2 more
core   +1 more source

A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans [PDF]

, 2008
Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Persaud, Shanta J.; id_orcid, Jones, Peter M.; id_orcid, Kitsou-Mylona, Isidora, Squires, Paul E., Jones, Peter M., Burns, Christopher J., Persaud, Shanta J.   +6 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Sphingomyelinases and Liver Diseases

Biomolecules, 2020
Sphingolipids (SLs) are critical components of membrane bilayers that play a crucial role in their physico-chemical properties. Ceramide is the prototype and most studied SL due to its role as a second messenger in the regulation of multiple signaling ...
Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa   +3 more
doaj   +1 more source

Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

Nature Communications, 2022
Chromosomal structural variations induced by CRISPR/Cas hinder its application in clinics. Here, the authors fuse Cas9 with optimized TREX2 to generate Cas9TX, which can prevent perfect repair and inhibit repeated cleavage.
Jianhang Yin, Rusen Lu, Changchang Xin, Yuhong Wang, Xinyu Ling, Dong Li, Weiwei Zhang, Mengzhu Liu, Wutao Xie, Lingyun Kong, Wen Si, Ping Wei, Bingbing Xiao, Hsiang-Ying Lee, Tao Liu, Jiazhi Hu   +15 more
doaj   +1 more source

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L., Koval, M., Johnstone, S.R., Kroncke, B.M., Isakson, B.E., Dunn, C.A., Nakamoto, R.K., Straub, A.C., Best, A.K., Lampe, P.D., Lo, C.W., Peskova, Y., Mitchell, L.A.   +12 more
core   +1 more source

Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching [PDF]

, 2012
Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial.
DI LAURO M. V., Maria Vittoria Di Lauro (127364), Teresa Iuvone (127378), Angelo Guglielmotti, Angelo Guglielmotti (127381), Pasquale Maffia (127384), Gianluca Grassia (127362), Cicala, C., MADDALUNO, MARCELLA, Francesco Maione, Maria Vittoria Di Lauro, Nicola Mascolo, Nicola Mascolo (127387), Maffia, P., Gianluca Grassia, Armando Ialenti, Antonio Parisi (127365), GRASSIA, GIANLUCA, Guglielmotti, A., IALENTI, ARMANDO, Grassia, G., IUVONE, TERESA, MASCOLO, NICOLA DOMENICO C. FERDINANDO, Carla Cicala (127370), Pasquale Maffia, MAIONE, FRANCESCO, Maione, F., Iuvone, T., Maddaluno, M., GUGLIELMOTTI A., Daniele De Filippis (127374), De Filippis, D., Antonio Parisi, Carla Cicala, Armando Ialenti (127390), Ialenti, A., Parisi, A., CICALA, CARLA, MAFFIA, PASQUALE, Marcella Maddaluno (127360), Marcella Maddaluno, Teresa Iuvone, PARISI A., Mascolo, N., Francesco Maione (127366), Di Lauro, M.V., Daniele De Filippis, DE FILIPPIS, DANIELE   +47 more
core   +1 more source