Results 41 to 50 of about 19,324,791 (349)
Cell, 2015 Summary The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear.
Kıvanç Birsoy +5 more
semanticscholar +1 more source
Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming
eLife, 2018 Understanding how cellular identity naturally interconverts with high efficiency and temporospatial precision is crucial for regenerative medicine. Here, we revealed a natural midgut-to-renal lineage conversion event during Drosophila metamorphosis and ...
Ke Xu +4 more
doaj +1 more source
Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
Oncogenesis, 2017 Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and signaling. Various oncogenic pathways such as proliferation and evading cell death converge on redox-dependent signaling processes.
Z. Fan +6 more
semanticscholar +1 more source
Auxilin regulates intestinal stem cell proliferation through EGFR
, 2022 [[abstract]]Adult tissue homeostasis is maintained by residential stem cells. The proliferation and differentiation of adult stem cells must be tightly balanced to avoid excessive proliferation or premature differentiation.
Zhao, H;Ren, X;Kong, R;Shi, L;Li, Z;Wang, R;Ma, R;Zhao, H;Liu, F;Chang, HC;Chen, CH;Li, Z
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]
, 1993 We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Lane, P. +5 more
core +2 more sources
The Expression Regulation and Biological Function of Autotaxin
Cells, 2021 Autotaxin (ATX) is a secreted glycoprotein and functions as a key enzyme to produce extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled receptors, LPAR1-6, on the cell membrane to activate various signal ...
Xiaotian Zhang +3 more
doaj +1 more source
Cell Proliferation in Neuroblastoma [PDF]
Cancers, 2016 Neuroblastoma, the most common extracranial solid tumor of childhood, continues to carry a dismal prognosis for children diagnosed with advanced stage or relapsed disease. This review focuses upon factors responsible for cell proliferation in neuroblastoma including transcription factors, kinases, and regulators of the cell cycle.
Stafman, Laura L., Beierle, Elizabeth A.
openaire +2 more sources
Cell Death and Disease, 2018 Noncoding RNAs plays an important role in hepatocellular carcinoma (HCC). Here, we show that miR-124 was downregulated in HCC tissues and that the ectopic expression of miR-124 inhibited the proliferation and migration of HCC cells.
Gen-wen Chen +3 more
semanticscholar +1 more source
Role of MOB4 in cell proliferation and neurogenesis [PDF]
, 2023 Signaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis.
Oliveira, Bruna +4 more
core +1 more source