Results 41 to 50 of about 2,026,518 (314)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labeled glucose.

, 2009
Cell proliferation may be measured in vivo by quantifying DNA synthesis with isotopically labeled deoxyribonucleotide precursors. Deuterium-labeled glucose is one such precursor which, because it achieves high levels of enrichment for a short period, is ...
Defoiche, Julien, Macallan, DC, de Lara, C, Asquith, B, Macallan, Derek C, Beverley, Peter, Beverley, Peter CL, Zhang, Y, Ghattas, H, Hala Ghattas, Becca Asquith, Defoiche, J, de Lara, Catherine, Asquith, Becca, Julien Defoiche, Derek C Macallan, Ghattas, Hala, Yan Zhang, Peter C L Beverley, Catherine de Lara, Zhang, Yan   +20 more
core   +1 more source

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Lane, P., T Brocker, McConnell, F., S Hubele, F McConnell, Padovan, E., P Lane, E Padovan, Lanzavecchia, A., Brocker, Thomas, A Lanzavecchia, Hubele, S.   +11 more
core   +1 more source

CircADAMTS16 Inhibits Differentiation and Promotes Proliferation of Bovine Adipocytes by Targeting miR-10167-3p

, 2023
Circular RNAs (CircRNAs) are covalently closed-loop non-coding RNA (ncRNA) molecules present in eukaryotes. Numerous studies have demonstrated that circRNAs are important regulators of bovine fat deposition, but their precise mechanisms remain unclear ...
Yun Ma, Chunli Hu, Yanfen Ma, Shuzhe Wang, Lingkai Zhang, Xue Feng, Dawei Wei   +6 more
core   +1 more source

Dendritic cell MST1 inhibits Th17 differentiation

Nature Communications, 2017
The differentiation of Th17 cells is central to infection and autoimmunity. Here, the authors show that expression of MST1 by dendritic cells limits IL-6 production and thereby controls Th17 differentiation in immunity to fungal infection and ...
Chunxiao Li, Yujing Bi, Yan Li, Hui Yang, Qing Yu, Jian Wang, Yu Wang, Huilin Su, Anna Jia, Ying Hu, Linian Han, Jiangyuan Zhang, Simin Li, Wufan Tao, Guangwei Liu   +14 more
doaj   +1 more source

A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis

Frontiers in Microbiology, 2022
The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li, Qian Huang, Weidi Zhang, Yinghua Cao, Zhanxin Wang, Zhenwen Zhao, Xiaotian Zhang, Junjie Zhang   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Sphingomyelinases and Liver Diseases

Biomolecules, 2020
Sphingolipids (SLs) are critical components of membrane bilayers that play a crucial role in their physico-chemical properties. Ceramide is the prototype and most studied SL due to its role as a second messenger in the regulation of multiple signaling ...
Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa   +3 more
doaj   +1 more source

Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis

Cells, 2022
Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver disease and two of the most prevalent forms of chronic liver disease.
Sandra Torres, Paula Segalés, Carmen García-Ruiz, José C. Fernández-Checa   +3 more
doaj   +1 more source

The centrosome and cell proliferation.

Cell division, 2006
Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or a consequence of cancer is unclear.
Merdes Andreas, Srsen Vlastimil
openaire   +3 more sources