Results 51 to 60 of about 7,279,295 (308)

Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

eLife
Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study,
Wencong Lyu, Haochen Wang, Zhehao Du, Ran Wei, Jianuo He, Fanju Meng, Jinlong Bi, Lijun Zhang, Chao Zhang, Yiting Guan, Wei Tao   +10 more
doaj   +1 more source

Auxilin regulates intestinal stem cell proliferation through EGFR

, 2022
[[abstract]]Adult tissue homeostasis is maintained by residential stem cells. The proliferation and differentiation of adult stem cells must be tightly balanced to avoid excessive proliferation or premature differentiation.
Zhao, H;Ren, X;Kong, R;Shi, L;Li, Z;Wang, R;Ma, R;Zhao, H;Liu, F;Chang, HC;Chen, CH;Li, Z, Lin Shi, Henry C. Chang, Huiqing Zhao, Liu, Fuli, Chang, Henry C., Shi, Lin, Rui Ma, Li, Zhengran, Hang Zhao, Kong, Ruiyan, Chun-Hong Chen, Li, Zhouhua, Runqi Wang, Fuli Liu, Xuejing Ren, Zhouhua Li, Ren, Xuejing, Ruiyan Kong, Zhao, Huiqing, Chen, Chun-Hong, Wang, Runqi, Zhao, Hang, Ma, Rui, Zhengran Li   +24 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L., Koval, M., Johnstone, S.R., Kroncke, B.M., Isakson, B.E., Dunn, C.A., Nakamoto, R.K., Straub, A.C., Best, A.K., Lampe, P.D., Lo, C.W., Peskova, Y., Mitchell, L.A.   +12 more
core   +1 more source

T-cell activation without proliferation in juvenile idiopathic arthritis [PDF]

, 2002
A study was done to determine if the differentiation and activation phenotype of T cells in synovial fluid (SF) from patients with juvenile idiopathic arthritis (JIA) is associated with T-cell proliferation in situ.
Black, Antony P.B., Ryder, Clive A.J., Bhayani, Hansha, Southwood, Taunton R., Gardner-Medwin, Janet M.M.   +4 more
core   +1 more source

p57(Kip2) imposes the reserve stem cell state of gastric chief cells

, 2022
Adult stem cells constantly react to local changes to ensure tissue homeostasis. In the main body of the stomach, chief cells produce digestive enzymes; however, upon injury, they undergo rapid proliferation for prompt tissue regeneration.
Ju, Young Seok, Caldwell, Brianna, Wu, Szu-Hsien Sam, Choi, Eunyoung, Stange, Daniel E., Park, JinYoung, Bamford, Aileen-Diane, Kim, Somi, Kim, Jihoon, An, Yohan, Bon-kyoung Koo, Kim, Jong Kyoung, Rocha, Andreia Sofia Batista, Pilat-Carotta, Sandra, Josserand, Manon, Lee, Heetak, Han, Seungmin, Lee, Ji-Hyun, Philpott, Anna, Fink, Juergen, Szep-Bakonyi, Réka, Min, Jimin, Koo, Bon-Kyoung, Lee, Sieun, Simons, Benjamin D., Aileen-Diane Bamford, Heetak Lee, Sandra Pilat-Carotta, Réka Szep-Bakonyi, Somi Kim, Jimin Min, Szu-Hsien Sam Wu, Juergen Fink, JinYoung Park, Seungmin Han, Eunyoung Choi, Jong Kyoung Kim, Andreia Sofia Batista Rocha, Anna Philpott, Ji-Hyun Lee, Daniel E. Stange, Benjamin D. Simons, Sieun Lee, Brianna Caldwell, Yohan An, Jihoon Kim, Young Seok Ju, Manon Josserand   +47 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

9X, regulates proliferation of cells of head and neck cancer lines

, 2016
Objectives Truncating mutations in USP9X have been identified in oral squamous cell carcinoma patients. The aim of this study was to determine USP9X's functional role, if any, in head and neck cancer cells.
Wood, SA, D. M. Nanayakkara, S. A. Wood, Nanayakkara, DM, Nguyen, MN, M. N. Nguyen   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science
Intestinal epithelial cells (IEC) are crucial for regulating intestinal local immunity to potentiate mucosal barrier function, but the mechanism remains unclear.
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
doaj   +1 more source