Results 51 to 60 of about 2,032,190 (314)

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Lane, P., T Brocker, McConnell, F., S Hubele, F McConnell, Padovan, E., P Lane, E Padovan, Lanzavecchia, A., Brocker, Thomas, A Lanzavecchia, Hubele, S.   +11 more
core   +1 more source

A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis

Frontiers in Microbiology, 2022
The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li, Qian Huang, Weidi Zhang, Yinghua Cao, Zhanxin Wang, Zhenwen Zhao, Xiaotian Zhang, Junjie Zhang   +7 more
doaj   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Interaction Between Malat1 and miR-499-5p Regulates Meis1 Expression and Function with a Net Impact on Cell Proliferation [PDF]

Meis1 is a transcription factor involved in numerous functions including development and proliferation and has been previously shown to harness cell cycle progression. In this study, we used in silico analysis to predict that miR-499-5p targets Meis1 and
Sameh Magdeldin, Injie Omar Fawzy, Salma A. Fahim, Rana Metwale, Aya Osama, Shereen Ahmed El Sobky, Hesham A. Sadek, Ahmed Karam, Ahmed Ihab Abdelaziz, Manon Ragheb, Mohamed Dief Allah Abdalmoneam Elsayed, Ahmed Abdellatif, Nada El-Ekiaby, Ibrahim Hassan Fayed   +13 more
core   +1 more source

Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis

Cells, 2022
Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver disease and two of the most prevalent forms of chronic liver disease.
Sandra Torres, Paula Segalés, Carmen García-Ruiz, José C. Fernández-Checa   +3 more
doaj   +1 more source

The centrosome and cell proliferation.

Cell division, 2006
Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or a consequence of cancer is unclear.
Merdes Andreas, Srsen Vlastimil
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

eLife
Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study,
Wencong Lyu, Haochen Wang, Zhehao Du, Ran Wei, Jianuo He, Fanju Meng, Jinlong Bi, Lijun Zhang, Chao Zhang, Yiting Guan, Wei Tao   +10 more
doaj   +1 more source

Sphingomyelinases and Liver Diseases

Biomolecules, 2020
Sphingolipids (SLs) are critical components of membrane bilayers that play a crucial role in their physico-chemical properties. Ceramide is the prototype and most studied SL due to its role as a second messenger in the regulation of multiple signaling ...
Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source