Results 1 to 10 of about 239,426 (300)

High MYC mRNA expression is more clinically relevant than MYC DNA amplification in triple-negative breast cancer [PDF]

, 2019
DNA abnormalities are used in inclusion criteria of clinical trials for treatments with specific targeted molecules. MYC is one of the most powerful oncogenes and is known to be associated with triple-negative breast cancer (TNBC).
Dasgupta, Subhamoy, Katsuta, Eriko, McDonald, Kerry-Ann, Opyrchal, Mateusz, Takabe, Kazuaki, Takeshita, Takashi, Yan, Li   +6 more
core   +2 more sources

Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types [PDF]

, 2017
In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many ...
Bose, Ron, Kumar, Runjun D
core   +2 more sources

Clinico-genomic findings, molecular docking, and mutational spectrum in an understudied population with breast cancer patients from KP, Pakistan

Frontiers in Genetics
In this study, we report the mutational profiles, pathogenicity, and their association with different clinicopathologic and sociogenetic factors in patients with Pashtun ethnicity for the first time. A total of 19 FFPE blocks of invasive ductal carcinoma
Hilal Ahmad, Asif Ali, Asif Ali, Asif Ali, Ali Talha Khalil, Roshan Ali, Ishaq Khan, Mah Muneer Khan, Ibrar Ahmed, Ibrar Ahmed, Zarrin Basharat, Mohammed Alorini, Amna Mehmood   +12 more
doaj   +1 more source

Humphrey Center News: Fall 1989 v. 4, no. 2 [PDF]

, 1989
Newsletter of the Hubert H.
Anthony, Richard P., Hubert H. Humphrey Cancer Research Center of Boston University   +1 more
core  

Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma. [PDF]

, 2019
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer histotype, characterized by high biological aggressiveness and scarce treatment options.
Calvisi, Diego F, Che, Li, Chen, Xin, Evert, Matthias, Hu, Junjie, Liu, Xianqiong, Lu, Xinjun, Song, Xinhua, Su, Tao, Utpatel, Kirsten, Wang, Jingxiao, Wang, Pan, Xu, Meng, Zhang, Jie, Zhang, Yi   +14 more
core   +1 more source

The role of ras gene in the development of haemic neoplasia in Mytilus trossulus [PDF]

, 2006
Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown.
Barber, Bos, Ciocan, Corina M. Ciocan, Elston, James D. Moore, Jeanette M. Rotchell, Moore, St-Jean, Van Beneden   +9 more
core   +2 more sources

On dynamic network entropy in cancer [PDF]

, 2012
The cellular phenotype is described by a complex network of molecular interactions. Elucidating network properties that distinguish disease from the healthy cellular state is therefore of critical importance for gaining systems-level insights into ...
A Califano, A Platzer, A Subramanian, AE Teschendorff, AL Barabasi, AR Lucena-Araujo, C Yao, CP Gully, D Hanahan, DP Tuck, DR Rhodes, E Wurmbach, EG Cerami, F Chung, G Schramm, GK Smyth, HS Park, HY Chuang, I Ulitsky, IW Taylor, J Ahmed, J Barretina, J Dutkowski, J Luo, J Luo, K Kandasamy, K Komurov, L Badea, L Demetrius, L Demetrius, L Milanesi, L Scotto, LD Wood, M D'Errico, M Sanchez-Carbayo, MA Pujana, MJ Garnett, MT Landi, NJ Hudson, O Morozova, P Tieri, Q Cui, RK Nibbe, S Bandyopadhyay, S Brin, SM Lens, T Ideker, T Manke, T Manke, TS Prasad, WN van Wieringen   +50 more
core   +2 more sources

Oncogenes in immune cells as potential therapeutic targets

ImmunoTargets and Therapy, 2018
Gulnur K Zakiryanova,1 Sarah Wheeler,2 Michael R Shurin2 1Department Biophysics and Biomedicine, Faculty Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan; 2Division of Clinical Immunopathology, Department of Pathology ...
Zakiryanova GK, Wheeler S, Shurin MR
doaj  

Utilizing RNA-Seq Data for Cancer Network Inference

, 2012
An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe the expression
Atwal, Gurinder S., Cai, Ying, Fendler, Bernard   +2 more
core   +1 more source

ESF-EMBO symposium "molecular biology and innovative therapies in sarcomas of childhood and adolescence" Sept 29–Oct 4, Polonia Castle Pultusk, Poland [PDF]

, 2013
Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic ...
Fulda, Simone, Koscielniak, Ewa, Kovar, Heinrich, Schäfer, Beat W.   +3 more
core   +2 more sources