Results 1 to 10 of about 30,889 (150)

Amplification of cycline D1, c-myc and EGFR oncogenes in tumour samples of breast cancer patients [PDF]

Journal of Medical Biochemistry, 2013
Background: Breast cancer is the most common form of cancer in women. It arises from multiple genetic changes in oncogenes and tumor suppressor genes.
Tanić Nasta, Milinković Vedrana, Dramićanin Tatjana, Nedeljković Milica, Stanković Tijana, Milovanović Zorka, Šušnjar Snežana, Milošević Verica, Šosić-Jurjević Branka, Džodić Radan, Tanić Nikola   +10 more
doaj  

Role of DNA Methylation in the Resistance to Therapy in Solid Tumors

Frontiers in Oncology, 2020
Despite the recent advances in chemotherapeutic treatments against cancer, some types of highly aggressive and invasive cancer develop drug resistance against conventional therapies, which continues to be a major problem in the fight against cancer.
Susana Romero-Garcia, Heriberto Prado-Garcia, Angeles Carlos-Reyes   +2 more
doaj   +1 more source

The Role of the Matrix Metalloproteinase-9 Gene in Tumor Development and Metastasis: A Narrative Review

Global Medical Genetics, 2023
Matrix metalloproteinase-9 (MMP-9) is one of the widely studied enzymes of the extracellular matrix which can degrade various matrix biomolecules. The gene coding for this enzyme has been found to be associated with various multifactorial diseases ...
Datis Kalali
doaj   +1 more source

Transcriptional Regulation of Energy Metabolism in Cancer Cells

Cells, 2019
Cancer development, growth, and metastasis are highly regulated by several transcription regulators (TRs), namely transcription factors, oncogenes, tumor-suppressor genes, and protein kinases.
Sara Rodríguez-Enríquez, Álvaro Marín-Hernández, Juan Carlos Gallardo-Pérez, Silvia Cecilia Pacheco-Velázquez, Javier Alejandro Belmont-Díaz, Diana Xochiquetzal Robledo-Cadena, Jorge Luis Vargas-Navarro, Norma Angélica Corona de la Peña, Emma Saavedra, Rafael Moreno-Sánchez   +9 more
doaj   +1 more source

26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1) and 3 (PSMD3) as Putative Targets for Cancer Prognosis and Therapy

Cells, 2021
Ever since the ubiquitin proteasome system was characterized, efforts have been made to manipulate its function to abrogate the progression of cancer. As a result, the anti-cancer drugs bortezomib, carfilzomib, and ixazomib targeting the 26S proteasome ...
Andres J. Rubio, Alfonso E. Bencomo-Alvarez, James E. Young, Vanessa V. Velazquez, Joshua J. Lara, Mayra A. Gonzalez, Anna M. Eiring   +6 more
doaj   +1 more source

The oncogenic role of NOTCH1 as biomarker in oral squamous cell carcinoma and oral lichen planus

Dental Research Journal, 2023
Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with heterogeneous molecular pathogenesis. Oral lichen planus (OLP) is demonstrated potentially can transfer to OSCC malignant lesions.
Ensieh Sagheb Sadeghi, Fatemeh Saeid Nematpour, Nooshin Mohtasham, Farnaz Mohajertehran   +3 more
doaj   +1 more source

Bases moleculares del cáncer

Repertorio de Medicina y Cirugía, 2011
El cáncer es una enfermedad caracterizada por la proliferación anormal de células neoplásicas, dada en esencia por alteraciones genéticas y epigenéticas.
Otto Gabriel Monzón, Edmundo Mora Padilla, Lilian Torres Tobar, Luz Dary Gutiérrez, Cladelis Rubi   +4 more
doaj   +1 more source

Lessons to cancer from studies of leukemia and hematopoiesis

Frontiers in Cell and Developmental Biology, 2022
The starting point to describing the origin and nature of any cancer must be knowledge about how the normal counterpart tissue develops. New principles to the nature of hematopoietic stem cells have arisen in recent years.
Geoffrey Brown
doaj   +1 more source

Gene amplification in carcinogenesis

Genetics and Molecular Biology, 2006
Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to ...
Lucimari Bizari, Ana Elizabete Silva, Eloiza H. Tajara   +2 more
doaj   +1 more source

Post‐operative mortality and recurrence patterns in pancreatic cancer according to KRAS mutation and CDKN2A, p53, and SMAD4 expression

The Journal of Pathology: Clinical Research, 2023
Alterations in KRAS, CDKN2A (p16), TP53, and SMAD4 genes have been major drivers of pancreatic carcinogenesis. The clinical course of patients with pancreatic cancer in relation to these driver alterations has not been fully characterised in large ...
Yohei Masugi, Manabu Takamatsu, Mariko Tanaka, Kensuke Hara, Yosuke Inoue, Tsuyoshi Hamada, Tatsunori Suzuki, Junichi Arita, Yuki Hirose, Yoshikuni Kawaguchi, Yousuke Nakai, Atsushi Oba, Naoki Sasahira, Gaku Shimane, Tsuyoshi Takeda, Keisuke Tateishi, Sho Uemura, Mitsuhiro Fujishiro, Kiyoshi Hasegawa, Minoru Kitago, Yu Takahashi, Tetsuo Ushiku, Kengo Takeuchi, Michiie Sakamoto, for the GTK Pancreatic Cancer Study Group in Japan   +24 more
doaj   +1 more source