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The MDM2 gene amplification database [PDF]
Nucleic Acids Research, 1998 The p53 tumor suppressor gene is inactivated in human tumors by several distinct mechanisms. The best characterized inactivation mechanisms are: (i) gene mutation; (ii) p53 protein association with viral proteins; (iii) p53 protein association with the MDM2 cellular oncoprotein. The MDM2 gene has been shown to be abnormally up-regulated in human tumors
J, Momand +3 more
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circRNA meets gene amplification [PDF]
Non-coding RNA Investigation, 2018 Lung cancer remains the most common cause of cancer related death among both males and females globally accounting for 1.69 million deaths in 2015 (1). Of the different types of lung cancer, lung adenocarcinoma (LAC) is the most common (2). Given the prevalence and lethality of lung cancer the need to elucidate the mechanisms of this disease and to ...
Nicholas, Manguso +2 more
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Archives of Medical Science, 2019 Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and
Jian-Long Miao +3 more
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Mechanisms of Gene Duplication and Amplification [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Changes in gene copy number are among the most frequent mutational events in all genomes and were among the mutations for which a physical basis was first known. Yet mechanisms of gene duplication remain uncertain because formation rates are difficult to measure and mechanisms may vary with position in a genome.
Reams, Andrew B, Roth, John R
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Clinical and imaging features of a pedigree with spinocerebellar ataxia type 6
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 doi：10.3969/j.issn.1672⁃6731.2021.06 ...
YANG Yun⁃peng +2 more
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Evolution of Gene Expression after Gene Amplification [PDF]
Genome Biology and Evolution, 2015 We took a rather unique approach to investigate the conservation of gene expression of prolamin storage protein genes across two different subfamilies of the Poaceae. We took advantage of oat plants carrying single maize chromosomes in different cultivars, called oat-maize addition (OMA) lines, which permitted us to determine whether regulation of gene
Garcia, Nelson +3 more
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Frontiers in Pharmacology, 2019 This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities.
YunXiang Zhang +7 more
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Cancer Management and Research, 2018 Chenfei Zhou,1,* Xiaojing Feng,2,* Fei Yuan,3 Jun Ji,4 Min Shi,1 Yingyan Yu,4 Zhenggang Zhu,1,4 Jun Zhang1 1Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 2Department ...
Zhou C +7 more
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NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas
Pathology and Oncology ResearchThe neurotrophic tyrosine kinase receptor (NTRK) gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins.
Zoltán Lippai +5 more
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BiomedicinesBackground: Bordetella pertussis causes pertussis, a respiratory infection with whooping cough. Despite a high vaccine coverage, pertussis resurged post-COVID-19 pandemic.
Tomohiro Oishi, Takashi Nakano
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