Results 31 to 40 of about 860,814 (258)

Study of C-MYC amplification and expression in Iranian gastric cancer samples using CISH and IHC methods

Advanced Biomedical Research, 2015
Background: Gastric cancer is the fourth most frequent malignancy and the second cause of cancer-related mortality worldwide. It has been suggested that in gastric carcinogenesis, the C-MYC gene has an important function.
Malihea Khaleghian, Issa Jahanzad, Abbas Shakoori, Farid Azmoudeh Ardalan, Cyrus Azimi   +4 more
doaj   +1 more source

HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy

Journal of Translational Medicine, 2012
Background HER2 and TOP2A parameters (gene status, mRNA and protein expression) have individually been associated with the outcome of patients treated with anthracyclines.
Fountzilas George, Valavanis Christos, Kotoula Vassiliki, Eleftheraki Anastasia G, Kalogeras Konstantine T, Tzaida Olympia, Batistatou Anna, Kronenwett Ralf, Wirtz Ralph M, Bobos Mattheos, Timotheadou Eleni, Soupos Nikolaos, Pentheroudakis George, Gogas Helen, Vlachodimitropoulos Dimitrios, Polychronidou Genovefa, Aravantinos Gerasimos, Koutras Angelos, Christodoulou Christos, Pectasides Dimitrios, Arapantoni Petroula   +20 more
doaj   +1 more source

Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli

mBio, 2018
Although the TEM-1 β-lactamase (BlaTEM-1) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However,
Lisa M. Schechter, David P. Creely, Cherilyn D. Garner, Dee Shortridge, Hoan Nguyen, Lei Chen, Blake M. Hanson, Erica Sodergren, George M. Weinstock, W. Michael Dunne, Alex van Belkum, Shana R. Leopold   +11 more
doaj   +1 more source

High-Resolution Mapping of Genomic Imbalance and Identification of Gene Expression Profiles Associated with Differential Chemotherapy Response in Serous Epithelial Ovarian Cancer

Neoplasia: An International Journal for Oncology Research, 2005
Array comparative genomic hybridization (aCGH) and microarray expression profiling were used to subclassify DNA and RNA alterations associated with differential response to chemotherapy in ovarian cancer.
Marcus Bernardini, Chung-Hae Lee, Ben Beheshti, Mona Prasad, Monique Albert, Paula Marrano, Heather Begley, Patricia Shaw, Al Covens, Joan Murphy, Barry Rosen, Salomon Minkin, Jeremy A. Squire, Pascale F. Macgregor   +13 more
doaj   +1 more source

c-Myc-Induced Extrachromosomal Elements Carry Active Chromatin

Neoplasia: An International Journal for Oncology Research, 2003
Murine Pre-13 lymphocytes with experimentally activated MycER show both chromosomal and extrachromosomal gene amplification. In this report, we have elucidated the size, structure, functional components of c-Myc-induced extrachromosomal elements (EEs ...
Greg Smith, Cheryl Taylor-Kashton, Len Dushnicky, Stephen Symons, Jim Wright, Sabine Mai   +5 more
doaj   +1 more source

Assessment of Cyclin E Gene Amplification as a Biomarker in Isfahan Province Breast Cancer Patients [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Breast cancer is the most common cancer among women worldwide. Cell-cycle is controlled by regulatory proteins called cyclins and Cyclin-Dependent Kinases. Aberrant activity of cyclins plays an important role in cancer development
Goharik Torosian, Mansour Salehi, Massoud Houshmand   +2 more
doaj  

Mycophenolate mofetil for corticosteroid-resistant immune-related cystitis associated with tislelizumab: a case report

Frontiers in Immunology
Immune-related cystitis is an uncommon immune-related adverse event (irAE) linked to immune checkpoint inhibitors (ICIs), and managing cases refractory to corticosteroids remains clinically challenging due to the lack of standardized treatment guidelines.
Lingping Kong, Fanlu Meng, Jing Yang, Kunlong Tang, Jian Xu, Diansheng Zhong, Linlin Zhang   +6 more
doaj   +1 more source

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

Microbial Cell, 2019
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily be ...
Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxin Yan, Yi Yin, Andrés Aguilera, Juan Lucas Argueso, Catherine H. Freudenreich, Susan M. Gasser, Dmitry A. Gordenin, James E. Haber, Grzegorz Ira, Sue Jinks-Robertson, Megan C. King, Richard D. Kolodner, Andrei Kuzminov, Sarah AE Lambert, Sang Eun Lee, Kyle M. Miller, Sergei M. Mirkin, Thomas D. Petes, Susan M. Rosenberg, Rodney Rothstein, Lorraine S. Symington, Pawel Zawadzki, Nayun Kim, Michael Lisby, Anna Malkova   +47 more
doaj   +1 more source

MYCN gene amplification in rhabdomyosarcoma [PDF]

Cancer, 1994
Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is the clearest example of a clinically relevant oncogene mutation in any human cancer.The incidence and clinical significance of MYCN amplification in rhabdomyosarcoma ...
D, Driman, P S, Thorner, M L, Greenberg, S, Chilton-MacNeill, J, Squire   +4 more
openaire   +2 more sources

LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data

BMC Cancer, 2018
Background Somatic amplifications of the LYL1 gene are relatively common occurrences in patients who develop uterine corpus endometrial carcinoma (UCEC) as opposed to other cancers.
Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Jeong-Sun Seo   +9 more
doaj   +1 more source