Results 21 to 30 of about 1,302,502 (304)

circRNA meets gene amplification [PDF]

Non-coding RNA Investigation, 2018
Lung cancer remains the most common cause of cancer related death among both males and females globally accounting for 1.69 million deaths in 2015 (1). Of the different types of lung cancer, lung adenocarcinoma (LAC) is the most common (2). Given the prevalence and lethality of lung cancer the need to elucidate the mechanisms of this disease and to ...
Nicholas, Manguso, Armando E, Giuliano, Hisashi, Tanaka   +2 more
openaire   +2 more sources

Investigating the mechanisms of glyphosate resistance in goosegrass (Eleusine indica) population from South China

Journal of Integrative Agriculture, 2015
Glyphosate has been used worldwide for nearly 40 years, and 30 types of resistant weeds have been reported. Glyphosate is mass-produced and widely used in China, but few studies and reports on glyphosate-resistant weeds and resistance mechanisms exist ...
Chun ZHANG, Li FENG, Ting-ting HE, Cai-hong YANG, Guo-qi CHEN, Xing-shan TIAN   +5 more
doaj   +1 more source

IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

mBio, 2022
Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection.
Da-Wei Wei, Nai-Kei Wong, Yuqin Song, Gang Zhang, Chao Wang, Juan Li, Jie Feng   +6 more
doaj   +1 more source

NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma. [PDF]

, 2019
The MYC oncogene is dysregulated in approximately 30% of liver cancer. In an effort to exploit MYC as a therapeutic target, including in hepatocellular carcinoma (HCC), strategies have been developed on the basis of MYC amplification or gene ...
Bodzin, Adam S., Budhu, Anuradha, Dang, Hien, Dominguez, Dana A., Lee, Ju-Seog, Martin, Sean P., Pomyen, Yotsawat, Shah, Ashesh P., Wang, Xin Wei, Yim, Sun Young   +9 more
core   +3 more sources

The Prognostic Value and Overexpression of Cyclin A Is Correlated with Gene Amplification of both Cyclin A and Cyclin E in Breast Cancer Patient

Cellular Oncology, 2006
Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously ...
A. Husdal, G. Bukholm, I. R. K. Bukholm
doaj   +1 more source

RNA pre-amplification enables large-scale RT-qPCR gene-expression studies on limiting sample amounts [PDF]

, 2009
Background : The quantitative polymerase chain reaction (qPCR) is a widely utilized method for gene-expression analysis. However, insufficient material often compromises large-scale gene-expression studies. The aim of this study is to evaluate an RNA pre-
Vermeulen, Joëlle, Derveaux, Stefaan, Lefever, Steve, De Smet, Els, De Preter, Katleen, Yigit, Nurten, De Paepe, Anne, Pattyn, Filip, Speleman, Franki, Vandesompele, Jo   +9 more
core   +2 more sources

Study of C-MYC amplification and expression in Iranian gastric cancer samples using CISH and IHC methods

Advanced Biomedical Research, 2015
Background: Gastric cancer is the fourth most frequent malignancy and the second cause of cancer-related mortality worldwide. It has been suggested that in gastric carcinogenesis, the C-MYC gene has an important function.
Malihea Khaleghian, Issa Jahanzad, Abbas Shakoori, Farid Azmoudeh Ardalan, Cyrus Azimi   +4 more
doaj   +1 more source

Gene Amplification Uncovers Large Previously Unrecognized Cryptic Antibiotic Resistance Potential in E. coli

Microbiology Spectrum, 2021
The activation of unrecognized antibiotic resistance genes in the bacterial cell can give rise to antibiotic resistance without the need for major mutations or horizontal gene transfer.
Stacy A. Suarez, Adam C. Martiny
doaj   +1 more source

Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons [PDF]

, 2004
Background: Activation of proto-oncogenes by DNA amplification is an important mechanism in the development and maintenance of cancer cells. Until recently, identification of the targeted genes relied on labour intensive and time consuming positional ...
De Preter, Katleen, Pattyn, Filip, Berx, Geert, Strumane, Kristin, Menten, Björn, Van Roy, Frans, De Paepe, Anne, Speleman, Franki, Vandesompele, Jo   +8 more
core   +2 more sources

HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy

Journal of Translational Medicine, 2012
Background HER2 and TOP2A parameters (gene status, mRNA and protein expression) have individually been associated with the outcome of patients treated with anthracyclines.
Fountzilas George, Valavanis Christos, Kotoula Vassiliki, Eleftheraki Anastasia G, Kalogeras Konstantine T, Tzaida Olympia, Batistatou Anna, Kronenwett Ralf, Wirtz Ralph M, Bobos Mattheos, Timotheadou Eleni, Soupos Nikolaos, Pentheroudakis George, Gogas Helen, Vlachodimitropoulos Dimitrios, Polychronidou Genovefa, Aravantinos Gerasimos, Koutras Angelos, Christodoulou Christos, Pectasides Dimitrios, Arapantoni Petroula   +20 more
doaj   +1 more source