Results 21 to 30 of about 864,053 (256)

Gene Amplification Uncovers Large Previously Unrecognized Cryptic Antibiotic Resistance Potential in E. coli

Microbiology Spectrum, 2021
The activation of unrecognized antibiotic resistance genes in the bacterial cell can give rise to antibiotic resistance without the need for major mutations or horizontal gene transfer.
Stacy A. Suarez, Adam C. Martiny
doaj   +1 more source

Genome position and gene amplification [PDF]

Genome Biology, 2007
Abstract Background Amplifications, regions of focal high-level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however, the use of amplification as a mechanism for overexpression of a particular gene in ...
Gajduskova, Pavla, Snijders, Antoine M, Kwek, Serena, Roydasgupta, Ritu, Fridlyand, Jane, Tokuyasu, Taku, Pinkel, Daniel, Albertson, Donna G   +7 more
openaire   +2 more sources

Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli

mBio, 2018
Although the TEM-1 β-lactamase (BlaTEM-1) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However,
Lisa M. Schechter, David P. Creely, Cherilyn D. Garner, Dee Shortridge, Hoan Nguyen, Lei Chen, Blake M. Hanson, Erica Sodergren, George M. Weinstock, W. Michael Dunne, Alex van Belkum, Shana R. Leopold   +11 more
doaj   +1 more source

High-Resolution Mapping of Genomic Imbalance and Identification of Gene Expression Profiles Associated with Differential Chemotherapy Response in Serous Epithelial Ovarian Cancer

Neoplasia: An International Journal for Oncology Research, 2005
Array comparative genomic hybridization (aCGH) and microarray expression profiling were used to subclassify DNA and RNA alterations associated with differential response to chemotherapy in ovarian cancer.
Marcus Bernardini, Chung-Hae Lee, Ben Beheshti, Mona Prasad, Monique Albert, Paula Marrano, Heather Begley, Patricia Shaw, Al Covens, Joan Murphy, Barry Rosen, Salomon Minkin, Jeremy A. Squire, Pascale F. Macgregor   +13 more
doaj   +1 more source

c-Myc-Induced Extrachromosomal Elements Carry Active Chromatin

Neoplasia: An International Journal for Oncology Research, 2003
Murine Pre-13 lymphocytes with experimentally activated MycER show both chromosomal and extrachromosomal gene amplification. In this report, we have elucidated the size, structure, functional components of c-Myc-induced extrachromosomal elements (EEs ...
Greg Smith, Cheryl Taylor-Kashton, Len Dushnicky, Stephen Symons, Jim Wright, Sabine Mai   +5 more
doaj   +1 more source

Assessment of Cyclin E Gene Amplification as a Biomarker in Isfahan Province Breast Cancer Patients [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Breast cancer is the most common cancer among women worldwide. Cell-cycle is controlled by regulatory proteins called cyclins and Cyclin-Dependent Kinases. Aberrant activity of cyclins plays an important role in cancer development
Goharik Torosian, Mansour Salehi, Massoud Houshmand   +2 more
doaj  

Mycophenolate mofetil for corticosteroid-resistant immune-related cystitis associated with tislelizumab: a case report

Frontiers in Immunology
Immune-related cystitis is an uncommon immune-related adverse event (irAE) linked to immune checkpoint inhibitors (ICIs), and managing cases refractory to corticosteroids remains clinically challenging due to the lack of standardized treatment guidelines.
Lingping Kong, Fanlu Meng, Jing Yang, Kunlong Tang, Jian Xu, Diansheng Zhong, Linlin Zhang   +6 more
doaj   +1 more source

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

Microbial Cell, 2019
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily be ...
Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxin Yan, Yi Yin, Andrés Aguilera, Juan Lucas Argueso, Catherine H. Freudenreich, Susan M. Gasser, Dmitry A. Gordenin, James E. Haber, Grzegorz Ira, Sue Jinks-Robertson, Megan C. King, Richard D. Kolodner, Andrei Kuzminov, Sarah AE Lambert, Sang Eun Lee, Kyle M. Miller, Sergei M. Mirkin, Thomas D. Petes, Susan M. Rosenberg, Rodney Rothstein, Lorraine S. Symington, Pawel Zawadzki, Nayun Kim, Michael Lisby, Anna Malkova   +47 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data

BMC Cancer, 2018
Background Somatic amplifications of the LYL1 gene are relatively common occurrences in patients who develop uterine corpus endometrial carcinoma (UCEC) as opposed to other cancers.
Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Jeong-Sun Seo   +9 more
doaj   +1 more source