Results 21 to 30 of about 860,814 (258)

Gene amplification in carcinogenesis

Genetics and Molecular Biology, 2006
Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to ...
Lucimari Bizari, Ana Elizabete Silva, Eloiza H. Tajara   +2 more
doaj   +1 more source

Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases

Cancer Biology & Medicine, 2021
Objective: Dysfunction in fibroblast growth factor receptor (FGFR) signaling has been reported in diverse cancer types, including non-small cell lung cancer (NSCLC).
Zhen Zhou, Zichuan Liu, Qiuxiang Ou, Xue Wu, Xiaonan Wang, Yang Shao, Hongyan Liu, Yu Yang   +7 more
doaj   +1 more source

On the Role of RNA in Gene Amplification [PDF]

Proceedings of the National Academy of Sciences, 1972
A complex of ribosomal DNA with RNA has been isolated from ovaries of metamorphosing tadpoles of Xenopus laevis . The complex is disrupted by treatments that destroy hydrogen bonds, and the sedimentation of the DNA within the complex is sensitive to RNase.
R D, Brown, G P, Tocchini-Valentini
openaire   +4 more sources

A rare epidermal growth factor receptor (EGFR) gene mutation in small cell lung carcinoma patients

Biomedical Papers, 2022
Aim. Activating mutations in the epidermal growth factor receptor (EGFR) are predominantly detected in pulmonary adenocarcinoma and have been reported in small cell lung cancer (SCLC) for decades. This retrospective single-center study aimed to determine
Cheng-Cheng Hwang, Tsan-Yu Hsieh, Kun-Yang Yeh, Tzu-Ping Chen, Chung-Ching Hua, Liang-Che Chang, Jim-Ray Chen   +6 more
doaj   +1 more source

A Temporary Pause in the Replication Licensing Restriction Leads to Rereplication during Early Human Cell Differentiation

Cells, 2022
Gene amplifications in amphibians and flies are known to occur during development and have been well characterized, unlike in mammalian cells, where they are predominantly investigated as an attribute of tumors.
Marie Minet, Masood Abu-Halima, Yiqing Du, Julia Doerr, Christina Isted, Nicole Ludwig, Andreas Keller, Eckart Meese, Ulrike Fischer   +8 more
doaj   +1 more source

IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

mBio, 2022
Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection.
Da-Wei Wei, Nai-Kei Wong, Yuqin Song, Gang Zhang, Chao Wang, Juan Li, Jie Feng   +6 more
doaj   +1 more source

The Prognostic Value and Overexpression of Cyclin A Is Correlated with Gene Amplification of both Cyclin A and Cyclin E in Breast Cancer Patient

Cellular Oncology, 2006
Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously ...
A. Husdal, G. Bukholm, I. R. K. Bukholm
doaj   +1 more source

Investigating the mechanisms of glyphosate resistance in goosegrass (Eleusine indica) population from South China

Journal of Integrative Agriculture, 2015
Glyphosate has been used worldwide for nearly 40 years, and 30 types of resistant weeds have been reported. Glyphosate is mass-produced and widely used in China, but few studies and reports on glyphosate-resistant weeds and resistance mechanisms exist ...
Chun ZHANG, Li FENG, Ting-ting HE, Cai-hong YANG, Guo-qi CHEN, Xing-shan TIAN   +5 more
doaj   +1 more source

Genome position and gene amplification [PDF]

Genome Biology, 2007
Abstract Background Amplifications, regions of focal high-level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however, the use of amplification as a mechanism for overexpression of a particular gene in ...
Gajduskova, Pavla, Snijders, Antoine M, Kwek, Serena, Roydasgupta, Ritu, Fridlyand, Jane, Tokuyasu, Taku, Pinkel, Daniel, Albertson, Donna G   +7 more
openaire   +2 more sources

Gene Amplification Uncovers Large Previously Unrecognized Cryptic Antibiotic Resistance Potential in E. coli

Microbiology Spectrum, 2021
The activation of unrecognized antibiotic resistance genes in the bacterial cell can give rise to antibiotic resistance without the need for major mutations or horizontal gene transfer.
Stacy A. Suarez, Adam C. Martiny
doaj   +1 more source