Results 11 to 20 of about 3,599,711 (186)
Gene amplification in carcinogenesis [PDF]
Genetics and Molecular Biology, 2006 Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to ...
Lucimari Bizari +2 more
doaj +2 more sources
Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]
, 2003 Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Krishnan, S. +3 more
core +8 more sources
The use of Multiple Displacement Amplification to increase the detection and genotyping of Trypanosoma samples immobilised on FTA filters. [PDF]
, 2007 Whole genome amplification methods are a recently developed tool for amplifying DNA from limited template. We report its application in trypanosome infections, characterized by low parasitemias.
Sweeney, L. +7 more
core +8 more sources
Microarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies. [PDF]
, 2008 BACKGROUND: The amplification of bacterial RNA is required if complex host-pathogen interactions are to be studied where the recovery of bacterial RNA is limited.
Laing Ken +15 more
core +1 more source
Identification and validation of novel amplification target genes in human breast cancer [PDF]
, 2007 Gene amplification is a major mechanism for overexpression of potential oncogenes in cancer. Several amplifications have already been described in breast cancer.
Ruiz, Christian
core +1 more source
On the Role of RNA in Gene Amplification [PDF]
Proceedings of the National Academy of Sciences, 1972 A complex of ribosomal DNA with RNA has been isolated from ovaries of metamorphosing tadpoles of Xenopus laevis . The complex is disrupted by treatments that destroy hydrogen bonds, and the sedimentation of the DNA within the complex is sensitive to RNase.
R D, Brown, G P, Tocchini-Valentini
openaire +4 more sources
Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer. [PDF]
, 2013 The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells.
Friedrich Bootz +29 more
core +1 more source
Amplification of KCNMA1 : a potential therapeutic target in prostate cancer [PDF]
, 2007 Prostate cancer is the most common cancer in males and the second leading cause of cancer deaths in western countries. Although most prostate cancers initially respond well to androgen withdrawal, they become inevitably resistant to this treatment and ...
Bloch, Michael
core +1 more source
Cellular Oncology, 2006 Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously ...
A. Husdal, G. Bukholm, I. R. K. Bukholm
doaj +1 more source
Journal of Integrative Agriculture, 2015 Glyphosate has been used worldwide for nearly 40 years, and 30 types of resistant weeds have been reported. Glyphosate is mass-produced and widely used in China, but few studies and reports on glyphosate-resistant weeds and resistance mechanisms exist ...
Chun ZHANG +5 more
doaj +1 more source