Modulators of gene amplification alter evolution of antibiotic resistance in Staphylococcus aureus. [PDF]
PLoS GeneticsGene amplification is thought to be common in bacterial populations, providing a rapid and reversible mode of adaptation to diverse stresses, including the acquisition of antibiotic resistance.
Kalinga Pavan T Silva +2 more
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Gene Amplification in Tumor Cells: Developed De Novo or Adopted from Stem Cells [PDF]
Cells, 2022 Gene amplifications have been known for several decades as physiological processes in amphibian and flies, e.g., during eggshell development in Drosophila and as part of pathological processes in humans, specifically in tumors and drug-resistant cells ...
Ulrike Fischer, Eckart Meese
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Gene amplification in the premalignant stages of non-small cell lung cancer development [PDF]
Frontiers in OncologyLung cancer remains the leading cause of cancer-related mortality worldwide. Over the past decade, major advances in targeted and immune-based therapies have improved outcomes for patients with advanced non-small cell lung cancer (NSCLC).
Vanessa G. P. Souza +12 more
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Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in Tetrahymena [PDF]
Microorganisms, 2023 Locus-specific gene amplification and genome-wide endoreplication generate the elevated copy number of ribosomal DNA (rDNA, 9000 C) and non-rDNA (90 C) chromosomes in the developing macronucleus of Tetrahymena thermophila.
Xiangzhou Meng +2 more
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Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification [PDF]
Cell GenomicsSummary: Recent work by the ICGC-PCAWG consortium identified recurrent focal deletions in the BRD4 gene, decreasing expression despite increased copy number.
Jeremiah Wala +8 more
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Selective gene amplification [PDF]
Protein Engineering Design and Selection, 2007 We describe a system for directed evolution based on in vitro compartmentalisation in which amplification of a gene is coupled to the formation of product by the enzyme it encodes. This approach mimics the process of natural selection; 'fitter' genes--encoding more efficient enzymes--have more 'offspring'.
Bernard T, Kelly, Andrew D, Griffiths
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Microbiology Spectrum, 2022 Various forms of adaptive evolution occur in clinical isolates in response to the presence of antimicrobial drugs. Among a total of 171 CTX-M-9 group/family extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli blood isolates recovered ...
Eun-Jeong Yoon +5 more
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Analysis of DNA Polymerases Reveals Specific Genes Expansion in Leishmania and Trypanosoma spp.
Frontiers in Cellular and Infection Microbiology, 2020 Leishmaniasis and trypanosomiasis are largely neglected diseases prevailing in tropical and subtropical conditions. These are an arthropod-borne zoonosis that affects humans and some animals and is caused by infection with protozoan of the genera ...
Ana Poveda +3 more
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Expression of Bcl-2 protein and the amplification of c-myc gene in patients with chronic myeloid leukemia [PDF]
Vojnosanitetski Pregled, 2006 Background/Aim. Chronic myeloid leukemia (CML) represents a malignant myeloproliferative disease developed out of pluripotent hematopoietic stem cell that contains the fusion bcr-abl gene. Disorders that occur in the process of apoptosis represent one of
Strnad Milica +5 more
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Prevalence of human papillomavirus infection of 65,613 women in East China
BMC Public Health, 2019 Background The infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China.
Yanmei Ge +5 more
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