Results 51 to 60 of about 3,599,711 (186)

Herceptest: HER2 expression and gene amplification in non-small cell lung cancer

, 2001
HER2 is an erbB/HER type I tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer ...
Askaa, J., Oster, A., Vyberg, M., O'Byrne, Kenneth J., Cox, G., Melgaard, B.   +5 more
core   +1 more source

IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

mBio, 2022
Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection.
Da-Wei Wei, Nai-Kei Wong, Yuqin Song, Gang Zhang, Chao Wang, Juan Li, Jie Feng   +6 more
doaj   +1 more source

SMAD5 Gene Expression, Rearrangements, Copy Number, Amplification at Fragile Site FRA5C in Human Hepatocellular Carcinoma

Neoplasia: An International Journal for Oncology Research, 2003
Signaling by the transforming growth factor (TGF)family members is transduced from the cell surface to the nucleus by the Smad group of intracellular proteins. Because we detected alterations on the long arm of chromosome 5, we examined the status of the
Drazen B. Zimonjic, Marian E. Durkin, Catherine L. Keck-Waggoner, Sang-Won Park, Snorri S. Thorgeirsson, Nicholas C. Popescu   +5 more
doaj   +1 more source

Mechanisms of Gene Duplication and Amplification [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
Changes in gene copy number are among the most frequent mutational events in all genomes and were among the mutations for which a physical basis was first known. Yet mechanisms of gene duplication remain uncertain because formation rates are difficult to measure and mechanisms may vary with position in a genome.
Reams, Andrew B, Roth, John R
openaire   +4 more sources

V-gene amplification revisited - An optimised procedure for amplification of rearranged human antibody genes of different isotypes.

, 2010
For studying human antibody variable (V)-gene usage in any group of individuals or for the generation of recombinant human antibody libraries for phage display, quality and yield of the amplified V-gene repertoire is of utmost importance.
Lehrach, H., Konthur, Z., Rubelt, F., Lim, T., Sievert, V., Dübel, S., Lim, T. S., Mollova, S.   +7 more
core   +1 more source

Advances in plant gene-targeted and functional markers: a review [PDF]

, 2013
Public genomic databases have provided new directions for molecular marker development and initiated a shift in the types of PCR-based techniques commonly used in plant science.
Ildikó Varga, Poczai, Péter, Neil Bell, Hyvönen Jaakko, Valkonen, Jari PT, Maarja Laos, Hyvönen, Jaakko, Cseh, András, Varga Ildikó, Varga, Ildikó, Laos, Maarja, Cseh András, Bell Neil, Poczai Péter, Valkonen, Jari, Cseh, András Attila, Péter Poczai, Jari PT Valkonen, Valkonen Jari PT, Jaakko Hyvönen, Bell, Neil, András Cseh, Laos Maarja   +22 more
core   +1 more source

Fibroblast Growth Factor Receptor 3 (FGFR3) Gene Amplification in Patients with Urothelial Carcinoma of the Urinary Bladder

The Iraqi Journal of Medical Sciences, 2021
Background: The fibroblast growth factor receptors (FGFRs) family includes five tyrosine kinase receptors, which play an important role in many cellular mechanisms including proliferation, migration and survival.
Mohsin A. Al-Marashi, Ban J. Qasim
doaj   +2 more sources

Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment

eLife, 2020
Evolutionary innovations allow populations to colonize new ecological niches. We previously reported that aerobic growth on citrate (Cit+) evolved in an Escherichia coli population during adaptation to a minimal glucose medium containing citrate (DM25 ...
Zachary D Blount, Rohan Maddamsetti, Nkrumah A Grant, Sumaya T Ahmed, Tanush Jagdish, Jessica A Baxter, Brooke A Sommerfeld, Alice Tillman, Jeremy Moore, Joan L Slonczewski, Jeffrey E Barrick, Richard E Lenski   +11 more
doaj   +1 more source

Analysis of specific gene by integration of isothermal amplification and electrophoresis on poly(methyl methacrylate) microchips

, 2004
We have successfully achieved the integration of isothermal amplification and the subsequent analysis of specific gene fragments on poly(methyl methacrylate) microchips.
Notomi, T, Hataoka, Y, Baba, Y, Zhang, LH, Mori, Y, Tomita, N, 张丽华   +6 more
core   +1 more source

Difference of molecular alterations in HER2-positive and HER2-negative gastric cancers by whole-genome sequencing analysis

Cancer Management and Research, 2018
Chenfei Zhou,1,* Xiaojing Feng,2,* Fei Yuan,3 Jun Ji,4 Min Shi,1 Yingyan Yu,4 Zhenggang Zhu,1,4 Jun Zhang1 1Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 2Department ...
Zhou C, Feng X, Yuan F, Ji J, Shi M, Yu Y, Zhu Z, Zhang J   +7 more
doaj