Results 61 to 70 of about 3,599,711 (186)

NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas

Pathology and Oncology Research
The neurotrophic tyrosine kinase receptor (NTRK) gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins.
Zoltán Lippai, Gergő Papp, Károly Szuhai, Johanna Sápi, Katalin Dezső, Zoltán Sápi   +5 more
doaj   +1 more source

Evolution of Gene Expression after Gene Amplification [PDF]

Genome Biology and Evolution, 2015
We took a rather unique approach to investigate the conservation of gene expression of prolamin storage protein genes across two different subfamilies of the Poaceae. We took advantage of oat plants carrying single maize chromosomes in different cultivars, called oat-maize addition (OMA) lines, which permitted us to determine whether regulation of gene
Garcia, Nelson, Zhang, Wei, Wu, Yongrui, Messing, Joachim   +3 more
openaire   +2 more sources

Analysis of Macrolide Resistance in Bordetella pertussis Isolated from Japanese Children in 2025 Using Test Kit and Sequence Method

Biomedicines
Background: Bordetella pertussis causes pertussis, a respiratory infection with whooping cough. Despite a high vaccine coverage, pertussis resurged post-COVID-19 pandemic.
Tomohiro Oishi, Takashi Nakano
doaj   +1 more source

Gene Expression in Neuroblastoma [PDF]

, 1996
The aim of this project is to identify potential target genes (NTG's) which may be regulated by in the cell line SK-N-SH which has no amplification of theoncogene N-myc.
Said, Sohair S.S.
core  

Analytical Validation of Quantitative Polymerase Chain Reaction and Ascent^TM Low-Pass Whole Genome Sequencing to Report on Gene Copy Number Variants in Cerebrospinal Fluid Tumor-Derived DNA

Journal of Molecular Pathology
Background: Evaluation of gene-level copy number variants (CNVs) for diagnosis and therapeutic decision making has become standard of care with next-generation sequencing (NGS), immunohistochemistry (IHC), and/or fluorescence in situ hybridization (FISH)
Viriya Keo, Sakshi Khurana, Vindhya Udhane, Alexandra Larson, Jennifer N. Adams, Daniel Sanchez, Tarin Peltier, Anthony Acevedo, Kathleen Mitchell, Kala F. Schilter, Qian Nie, Honey V. Reddi   +11 more
doaj   +1 more source

The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]

, 2008
We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
Joets, Johann, Moore, Jonathan D., Heslop-Harrison, J. (John), King , Graham J., Ryder, C. D., Heslop-Harrison, J. S., Joets, J., Bailey, John P., Moore, J., Ryder, Carol D., Bailey, J. P., Alix, K., Barker, G. C., King, G. J., Barker, Guy C., Alix, Karine   +15 more
core   +1 more source

Piperacillin-tazobactam resistance in Klebsiella pneumoniae is often associated with IS26-mediated blaSHV-1 amplification in a widespread Klebsiella-adapted plasmid

Antimicrobial Agents and Chemotherapy
Piperacillin-tazobactam (TZP) resistance in Klebsiella pneumoniae involves diverse mechanisms with unclear prevalence and phenotypic impact. To elucidate these mechanisms, we analyzed K.
Guilhem Royer, Maxime Danjean, Christophe Rodriguez, Vincent Fihman, Emmanuelle Gallois, Eve Tessier, Florence Reibel, Nicolas Cabanel, Philippe Glaser, Paul-Louis Woerther, Hervé Jacquier   +10 more
doaj   +1 more source

Aminoglycoside Heteroresistance in Acinetobacter baumannii AB5075

mSphere, 2018
Heteroresistance is a phenomenon where a subpopulation of cells exhibits higher levels of antibiotic resistance than the general population. Analysis of tobramycin resistance in Acinetobacter baumannii AB5075 using Etest strips demonstrated that colonies
Sarah E. Anderson, Edgar X. Sherman, David S. Weiss, Philip N. Rather   +3 more
doaj   +1 more source

Epidermal growth factor receptor in breast carcinoma: association between gene copy number and mutations

Diagnostic Pathology, 2011
Background The epidermal growth factor receptor (EGFR) is an available target of effective anti-EGFR therapy for human breast cancer. The aim of this study was to assess the presence of EGFR gene amplification and mutations in breast cancer and to ...
Lv Ning, Xie Xiaoming, Ge Qidong, Lin Suxia, Wang Xi, Kong Yanan, Shi Hongliu, Xie Xinhua, Wei Weidong   +8 more
doaj   +1 more source

Overexpression of blaSHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae

Emerging Microbes and Infections
We identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant Klebsiella pneumoniae isolated from a patient who had not been exposed CAZ/AVI.
Chao Liu, Juan Yi, Ping Yang, Chunjing Du, Fan Jiang, Ming Lu, Pengcheng Du, Ning Shen   +7 more
doaj   +1 more source