Oncogenes, Proto-Oncogenes, and Lineage Restriction of Cancer Stem Cells [PDF]
International Journal of Molecular Sciences, 2021 In principle, an oncogene is a cellular gene (proto-oncogene) that is dysfunctional, due to mutation and fusion with another gene or overexpression. Generally, oncogenes are viewed as deregulating cell proliferation or suppressing apoptosis in driving ...
Geoffrey Brown, Brown Geoffrey
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Coordinated Activation of Candidate Proto-Oncogenes and Cancer Testes Antigens via Promoter Demethylation in Head and Neck Cancer and Lung Cancer [PDF]
PLoS ONE, 2009 Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported.
Ian M Smith +2 more
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Proto-oncogenes in a eukaryotic unicellular organism play essential roles in plasmodial growth in host cells [PDF]
BMC Genomics, 2018 Background The eukaryotic unicellular protist Plasmodiophora brassicae is an endocellular parasite of cruciferous plants. In host cortical cells, this protist develops a unicellular structure that is termed the plasmodium.
Kai Bi +8 more
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Analyses of domains and domain fusions in human proto-oncogenes [PDF]
BMC Bioinformatics, 2009 Background Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers.
Wan Ping +5 more
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Activation of proto-oncogenes by disruption of chromosome neighborhoods. [PDF]
Science, 2016 Hnisz D +16 more
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Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer [PDF]
BiomedicinesBackground/Objectives: Cervical cancer (CC) remains a significant global health challenge, characterized by genetic heterogeneity and a complex molecular landscape, both of which contribute to its pathogenesis.
Ksenia Lenkova +6 more
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Japanese Journal of Cancer Research, 1992 We investigated the frequency of rearrangements of the ret and trk proto‐oncogenes in Japanese thyroid tumors. DNAs from 38 thyroid papillary carcinomas and 14 follicular adenomas were analyzed by Southern blotting.
Worawidh Wajjwalku +2 more
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Repeat-element driven activation of proto-oncogenes in human malignancies. [PDF]
Cell Cycle, 2010 Lamprecht B, Bonifer C, Mathas S.
europepmc +2 more sources
Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. [PDF]
Gut, 2014 Hur K +6 more
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Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
Liver Research, 2021 Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.
Fang Wang, Peter Breslin S J, Wei Qiu
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