Oncogenes, Proto-Oncogenes, and Lineage Restriction of Cancer Stem Cells [PDF]
International Journal of Molecular Sciences, 2021 In principle, an oncogene is a cellular gene (proto-oncogene) that is dysfunctional, due to mutation and fusion with another gene or overexpression. Generally, oncogenes are viewed as deregulating cell proliferation or suppressing apoptosis in driving ...
Geoffrey Brown
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Coordinated Activation of Candidate Proto-Oncogenes and Cancer Testes Antigens via Promoter Demethylation in Head and Neck Cancer and Lung Cancer [PDF]
PLoS ONE, 2009 Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported.
Victor V Lobanenkov +2 more
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Analyses of domains and domain fusions in human proto-oncogenes [PDF]
BMC Bioinformatics, 2009 Background Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers.
Wan Ping +5 more
doaj +5 more sources
Activation of proto-oncogenes by disruption of chromosome neighborhoods [PDF]
Science, 2016 Denes Hnisz +2 more
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Proto-oncogenes in a eukaryotic unicellular organism play essential roles in plasmodial growth in host cells [PDF]
BMC Genomics, 2018 Background The eukaryotic unicellular protist Plasmodiophora brassicae is an endocellular parasite of cruciferous plants. In host cortical cells, this protist develops a unicellular structure that is termed the plasmodium.
Kai Bi +8 more
doaj +2 more sources
Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer [PDF]
BiomedicinesBackground/Objectives: Cervical cancer (CC) remains a significant global health challenge, characterized by genetic heterogeneity and a complex molecular landscape, both of which contribute to its pathogenesis.
Ksenia Lenkova +6 more
doaj +2 more sources
Repeat-element driven activation of proto-oncogenes in human malignancies. [PDF]
Cell Cycle, 2010 Lamprecht B, Bonifer C, Mathas S.
europepmc +2 more sources
Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. [PDF]
Gut, 2014 Hur K +6 more
europepmc +2 more sources
Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
Liver Research, 2021 Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.
Fang Wang, Peter Breslin S J, Wei Qiu
doaj +1 more source
Reviewing Oncogenes and Proto-Oncogenes
International Journal of Scientific Research in Science and Technology, 2021 This article is an examination of the Reviewing oncogenes and Proto-oncogenes The scientific development and subsequent “oncogenes and Proto-oncogenes” continues to influence the researchers all over the globe today.
Neha Batra +3 more
semanticscholar +1 more source