Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma. [PDF]
, 2019 Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer histotype, characterized by high biological aggressiveness and scarce treatment options.
Calvisi, Diego F +14 more
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Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by resveratrol derivatives [PDF]
, 2012 As demonstrated previously, resveratrol (3,4',5-trihydroxy-trans-stilbene) inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC), the key rate limiting enzyme in mammalian polyamine synthesis.
John M. Pezzuto +4 more
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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation [PDF]
, 1995 The Ras and Raf1 proto-oncogenes transduce extracellular signals that promote cell growth. Cdc25 phosphatases activate the cell division cycle by dephosphorylation of critical threonine and tyrosine residues within the cyclin-dependent kinases.
Beach, D. +2 more
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Importância do vírus da leucemia felina na linfomagênese: Revisão
Pubvet, 2018 O vírus da Leucemia felina (FeLV) é um retrovírus oncogênico frequentemente relacionado ao linfoma em felinos domésticos. O principal mecanismo pelo qual o FeLV induz neoplasia é através da mutagênese insercional adquirida somaticamente, podendo o ...
Dayse Helena Lages da Silva +3 more
doaj +1 more source
Lung Cancer: A Literature Review
Jurnal Respirasi, 2023 Lung cancer is a cancer whose onset starts in the lungs where there is an abnormal cell growth that is very fast and uncontrolled. The abnormal cell growth is triggered by deoxyribonucleic acid (DNA) damage, including deletions in the DNA section ...
Yan Efrata Sembiring +8 more
doaj +1 more source
O PROTO-ONCOGENE RAS NO BÓCIO MULTINODULAR
Clinical and Biomedical Research, 2022 A transformação neoplásica resulta de uma série de alterações genéticas, envolvendo ativação de proto-oncogenes e inativação de genes supressores tumorais.
Lenara Golbert +5 more
doaj
Molecular Pathogenesis and Targeted Therapies in Well-Differentiated Thyroid Carcinoma [PDF]
Endocrinology and Metabolism, 2014 Four proto-oncogenes commonly associated with well-differentiated thyroid carcinoma, rearranged during transfection (RET)/papillary thyroid cancer, BRAF, RAS, and PAX8/peroxisome proliferator activated receptor-γ, may carry diagnostic and prognostic ...
Jung Guk Kim
doaj +1 more source
Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes.
Journal of Immunology, 1988 Adherence is an important regulatory signal for several monokines and the proto-oncogenes c-fms and c-fos in human peripheral blood monocytes. Although there is little if any constitutive expression of the IL-1 beta, TNF-alpha and CSF-1 genes in freshly ...
S. Haskill +4 more
semanticscholar +1 more source
Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons [PDF]
, 2004 Background: Activation of proto-oncogenes by DNA amplification is an important mechanism in the development and maintenance of cancer cells. Until recently, identification of the targeted genes relied on labour intensive and time consuming positional ...
De Preter, Katleen +8 more
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Hypoxic-ischemic encephalopathy: facts and insights [PDF]
, 2005 Asphyxia may cause a hypoxic-ischemic encephalopathy due to an insufficient supply of oxygenated blood to the brain, which leads to a cerebral palsy. The transition state between both is called neonatal encephalopathy.
Braems, Geert
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