Results 41 to 50 of about 111,107 (240)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Nature Communications, 2016 miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al.
Wen Cai Zhang +21 more
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Role of Molecular Biology in Cancer Treatment: A Review Article
Iranian Journal of Public Health, 2017 Background: Cancer is a genetic disease and mainly arises due to a number of reasons include activation of oncogenes, malfunction of tumor suppressor genes or mutagenesis due to external factors. Methods: This article was written from the data collected
Aman IMRAN +9 more
doaj
Научно-технический вестник информационных технологий, механики и оптикиThe loss of the regulatory function of tumor suppression genes and mutations in Proto-oncogene are the common underlying mechanisms for uncontrolled tumor growth in the varied complex of disorders known as cancer.
M. Vijayalakshmi, M. Vallinayagi
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The non-coding oncogene: a case of missing DNA evidence?
Frontiers in Genetics, 2012 The evidence that links classical protein-coding proto-oncogenes and tumor suppressors, such as MYC, RAS, P53, and RB, to carcinogenesis is indisputable. Multiple lines of proof show how random somatic genomic alteration of such genes (e.g.
Puja eShahrouki, Erik eLarsson
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Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12. [PDF]
PLoS ONE, 2011 Analysis of chromosomal rearrangements within primary tumors has been influential in the identification of novel oncogenes. Identification of the "driver" gene(s) within cancer-derived amplicons is, however, hampered by the fact that most amplicons ...
Erica L Cain +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Data in Brief, 2018 The c-mos proto-oncogene was one of the first proto-oncogenes to be cloned. Apart from its role in meiosis, many efforts have been made to illuminate the mechanisms by which c-mos might acts as an oncogene.
Zhengxi Chen +3 more
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