Results 61 to 70 of about 111,107 (240)
Variable finals in proto-Sino-Tibetan [PDF]
, 2010 This paper concentrates on variable finals, and argues that just as we find a certain amount of both rule-governed and non-rule governed variation in modern languages, in reconstructing Proto-Sino-Tibetan we should recognize the possibility of these ...
LaPolla, Randy J.
core
Proto-Jeh-Halang and Proto-North-Bahnaric revisited
, 1994 Scholars of Mon-Khmer historical phonology have traditionally complained about apparently poor vowel correspondences To deal with this problem in Bahnaric, quite low level reconstructions were done as a first step, and then these were compared for the ...
Paul Sidwell (7308455)
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development
Biology Open, 2018 The Plag gene family has three members; Plagl1/Zac1, which is a tumor suppressor gene, and Plag1 and Plagl2, which are proto-oncogenes. All three genes are known to be expressed in embryonic neural progenitors, and Zac1 regulates proliferation, neuronal ...
Lata Adnani +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Genetic aspects of etiology and development of thyroid gland cancer [PDF]
Саратовский научно-медицинский журнал, 2012 Recent studies on thyroid gland cancer development and progression have identified new classes of tumor markers, proto-oncogenes, tumor-suppressing genes, cell receptor genes, identified genetic tumor-predisposing polymorphism and some other ...
Kovalenko Yu.V., Tolstokorov A.S.
doaj
Cell Journal, 2018 Objective Pulegone (PGN) is a monoterpene ketone, whose metabolites exert several cytotoxic effects in various tissues. The present study was conducted in order to evaluate the (R)-(+) PGN-induced alterations in ovarian aromatization, proto-oncogenes ...
Rohiyeh Souldouzi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
An oncogene is a mutated form of a normal cellular gene – called a proto-oncogene – that contributes to the development of a cancer. Proto-oncogenes typically regulate cell growth and cell differentiation.
حسینی اصل, سید سعید
core
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source