Results 81 to 90 of about 325,026 (325)

Role of DNA methylation in cancer development and its clinical applications

Clinical and Translational Discovery
methyltransferase gene (DNA) methylation is a key process in epigenetic modification. This transformation leads to genomic instability that creates an impact on gene expression.
Swarup Sonar, Sidhanti Nyahatkar, Ketki Kalele, Manab Deb Adhikari   +3 more
doaj   +1 more source

Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes. [PDF]

Cancers (Basel), 2023
Alqahtani T, Kumarasamy V, Alghamdi SS, Suliman RS, Bin Saleh K, Alrashed MA, Aldhaeefi M, Sun D.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model

Bulletin of the National Research Centre
Background The second most common cancer in the world is breast cancer. Chemotherapy is used to treat breast cancer, but instances of multidrug resistance, targets that are not selective, and physicochemical issues raise doubts about its efficacy.
Aida I. El makawy, Sekena H. Abdel-Aziem, Shaimaa E. Mohammed, Faten M. Ibrahim, Heba A. Abd EL-Kader, Hafiza A. Sharaf, Dalia A. Youssef, Dalia M. Mabrouk   +7 more
doaj   +1 more source

Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review) [PDF]

Саратовский научно-медицинский журнал, 2011
The research work presents an analysis of literature review and results of investigations on the problems of etiology, pathogenesis, classification and peculiarities of clinical manifestations of chronic lymphocytic leukaemia.
Chesnokova N.P., Shelekhova T.V., Zhevak T.N.   +2 more
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Aneuploidías del cromosoma 17 y deleción del Gen TP53 en neoplasias hematológicas

Iatreia, 2006
La oncogénesis es considerada un proceo de múltiples etapas, en donde los factores genéticos son esenciales para su origen y desarrollo; se afectan principalmente dos grandes grupos de genes; se afectan principalmente dos grandes grupos de genes: los ...
Carlos Mario Muñetón Peña, José Luis Ramírez Castro, Gonzálo Vásquez Palacio, Gloria Ramírez Gaviria, Luis Fernando Isaza Jiménez, Juan Carlos Herrera Patiño   +5 more
doaj  

MECANISMOS FISIOPATOLÓGICOS EM NEOPLASIAS CUTÂNEAS RARAS: A INFLUÊNCIA DOS PROTO-ONCOGENES NO MELANOMA ACRAL E CARCINOMAS DE CÉLULAS DE MERKEL

Introdução: As neoplasias cutâneas raras, como o melanoma acral e o carcinoma de células de Merkel, representam desafios significativos no campo da oncologia devido à sua agressividade e baixa incidência.
Fechine Honorato, Pedro, Perez Molan, Marina, Rocha, Isleanne Pereira, Sousa, Maria Victória Alves Lima de, Peixoto Mariano , Bruna, Dalla Bernardina , Livia, Moura Teixeira , Pedro Henrique, Segadilha Prado , Douglas, Freitas , Paloma de Carvalho, Ribeiro de Freitas , Matheus Buissa   +9 more
core   +1 more source

Efeito do extrato de Microcystis aeruginosa na regulação de proto-oncogenes e supressores de tumor em peixe-zebra [PDF]

, 2016
As cianobactérias do gênero Microcystis produzem uma diversidade de cianotoxinas que causam efeitos adversos em animais, sendo a microcistina-LR (MC-LR) uma hepatotoxina muito estudada.
Fonseca, Viviane Barneche
core  

The Sustainability of University-Business Innovation Clusters: The Case of IoT Rapid-Proto Labs [PDF]

, 2020
The objective of this study is to identify sources of support for the IoT Rapid-Proto Labs to enable the success and sustainability of the project. This study is done for the European transnational multidisciplinary project IoT Rapid-Proto Labs, which ...
Lindberg, Christa
core