Prostate-specific membrane antigen modulates the progression of prostate cancer by regulating the synthesis of arginine and proline and the expression of androgen receptors and Fos proto-oncogenes. [PDF]
Bioengineered, 2022 Hong X, Mao L, Xu L, Hu Q, Jia R.
europepmc +1 more source
Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Advanced Materials, EarlyView.Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
wiley +1 more source
Diagnostic Biomarkers Related to Cancer Detection and Treatment: A Review Article
مجلة علوم ذي قار, 2021 Cancer is a serious problem affecting the health of all human societies. Thus the challenge is how the diagnosis and then who find effective treatment. Proto-oncogenes under abnormal condition turn out to be oncogenes throughout genetic mutation, which ...
.Suhad Faisal Hatem Al-Mugdadi
doaj
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
BiologyProto-oncogenes in the RAS superfamily play dual roles in maintaining cellular homeostasis, such as regulating growth signals and contributing to cancer development through proliferation and deregulation.
Richard A. McDonald +2 more
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Proto-Oncogenes and Cell Cycle Gene Expression in Normal and Neoplastic Oral Epithelial Cells Stimulated With Soluble Factors From Single and Dual Biofilms of Candida albicans and Staphylococcus aureus. [PDF]
Front Cell Infect Microbiol, 2021 Amaya Arbeláez MI +5 more
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The biology of the Ets1 proto-oncogene.
Molecular cancer, 2003 The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. Some transcription factors, such as AML-1, regulate Ets1 by targeting its autoinhibitory module.
openaire +5 more sources
, 2023 The rearranged during transfection (RET) proto-oncogene encodes a transmembrane receptor tyrosine kinase and its alterations cause various cancers and developmental disorders. Gain-of-function mutations caused by gene rearrangements have been found in papillary thyroid carcinoma, non-small-cell lung carcinoma, and other cancers, while point mutations ...
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Impact of Amplified Oncogenes on Salivary Gland Carcinomas
, 2023 In normal epithelia, proto-oncogenes regulate critical intra-or intercellular functions, including cell growth and proliferation, apoptosis, and signaling transduction from the cell periphery (extracellular space) to the nucleus mediated by different ...
Mastronikoli, Sofianiki +16 more
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