Results 101 to 110 of about 111,107 (240)

Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia

npj Precision Oncology
Acute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes.
Ashlee Thomson, Jacqueline Rehn, David Yeung, James Breen, Deborah White   +4 more
doaj   +1 more source

RET proto-oncogene

, 2023
The rearranged during transfection (RET) proto-oncogene encodes a transmembrane receptor tyrosine kinase and its alterations cause various cancers and developmental disorders. Gain-of-function mutations caused by gene rearrangements have been found in papillary thyroid carcinoma, non-small-cell lung carcinoma, and other cancers, while point mutations ...
openaire   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Impact of Amplified Oncogenes on Salivary Gland Carcinomas

, 2023
In normal epithelia, proto-oncogenes regulate critical intra-or intercellular functions, including cell growth and proliferation, apoptosis, and signaling transduction from the cell periphery (extracellular space) to the nucleus mediated by different ...
Mastronikoli, Sofianiki, Mastronikolis, Nicholas, Manaios, Loukas, Fotiades, Panagiotis, Vylliotis, Antonis, Papouliakos, Sotirios, Spyropoulou, Despoina, Asimakopoulos, Asimakis D., Kyrodimos, Efthymios, Tsiambas, Evangelos, Papanastasiou, George, Roukas, Dimitrios, Papanikolaou, Vasileios, Pantos, Pavlos, Peschos, Dimitrios, Chrysovergis, Aristeidis, Ragos, Vasileios   +16 more
core   +1 more source

RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS: A Narrative Review of the Complexities and Functions of the Family of RAS Genes and Ras Proteins in Housekeeping and Tumorigenesis

Biology
Proto-oncogenes in the RAS superfamily play dual roles in maintaining cellular homeostasis, such as regulating growth signals and contributing to cancer development through proliferation and deregulation.
Richard A. McDonald, Armando Varela-Ramirez, Amanda K. Ashley   +2 more
doaj   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Mechanism of Malignant Transformation in Bronchial Epithelial Cells Induced by The Environmental Carcinogen B[α]PDE

Shengwu huaxue yu shengwu wuli jinzhan
Benzo[a]pyrene (B[α]P) is a common environmental carcinogen, mainly from the smoke generated by the incomplete combustion of coal, oil and natural gas in the industrial production and living process, which undergoes a series of metabolic reactions in ...
YIN Zhang-Ya, LI Cong-Ya, ZHU Jun-Lan
doaj   +1 more source

Geography & the Web

, 2018
Communication weaves the connections between new spatial relations, and creates new meanings and new imaginaries. The contemporary process of communication is giving substance to a model of society which identifies itself in the vast multimedia sea where
Albanese V., Greco V., Proto M., Albanese, V, Greco, V, Proto, M   +3 more
core  

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.

, 1987
DNAs from fifty-three primary breast cancers were hybridized with 16 different proto-oncogene or oncogene probes. Abnormalities of one or more of five proto-oncogenes were found in fifty-eight percent of tumors at the time of mastectomy.
J Yokota, M J Cline, H Battifora
core   +1 more source