Results 121 to 130 of about 325,026 (325)

Camptothecin preferentially inhibits large genes such as proto-oncogenes and anti-apoptotic genes, enhances the relative expression of small pro-apoptotic genes and activates the p53 response.

, 2013
(A), Examples of large proto-oncogenes inhibited by camptothecin and showing no recovery (or slow recovery) following drug removal. (B), Examples of p53 target genes induced following camptothecin treatment.
Benjamin Biewen (476021), Nathan Berg (476023), Artur Veloso (476020), Jayendra Prasad (29161), Brian Magnuson (476026), Karan Bedi (476025), Mats Ljungman (36206), Thomas E. Wilson (134623), Michelle T. Paulsen (476022), Leonardo Carmo de Andrade Lima (476024)   +9 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Biología del cáncer

Correo Científico Médico, 2019
El cáncer constituye un problema de salud con gran impacto humano y económico. La mortalidad por cáncer ha aumentado sostenidamente en los últimos 25 años a nivel mundial.
Alejandro Bermúdez Garcell, Nilvia Bienvenida Serrano Gámez, Rolando Teruel Ginés, María de los Ángeles Leyva Montero, Anthony Alfonso Naranjo Coronel   +4 more
doaj   +2 more sources

Toward Proto-Nostratic A New Approach to the Comparison of Proto-Indo-European and Proto Afroasiatic

TOWARD PROTO-NOSTRATIC -- Editorial page -- Title page -- Copyright page -- FOREWORD -- PREFACE -- Table of contents -- 1. INTRODUCTION -- 1.1. PREFATORY REMARKS -- 1.2. THE INDO-EUROPEAN LANGUAGES -- 1.3. THE AFROASIATIC LANGUAGES -- 2.
Bomhard, Alan R., Hopper, Paul J.
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

An outline of Proto-Indo-European

, 2010
Indo-European is a branch of Indo-Uralic which was radically transformed under the influence of a North Caucasian substratum when its speakers moved from the area north of the Caspian Sea to the area north of the Black Sea (cf. Kortlandt 2007b).
Kortlandt, Frederik H. H.
core  

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Extracellular Vesicles of Human Periodontal Ligament Stem Cells Contain MicroRNAs Associated to Proto-Oncogenes: Implications in Cytokinesis. [PDF]

Front Genet, 2020
Chiricosta L, Silvestro S, Gugliandolo A, Marconi GD, Pizzicannella J, Bramanti P, Trubiani O, Mazzon E.   +7 more
europepmc   +1 more source

Il conto corrente come strumento di gestione dei rapporti banca - cliente [PDF]

, 2018
Presentazione delle caratteristiche tecniche del conto corrente bancario. Analisi delle condizioni economiche che determinano il costo effettivo per il cliente.
Proto, Antonio, Antonio Proto
core