Results 111 to 120 of about 111,107 (240)

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Toward Proto-Nostratic A New Approach to the Comparison of Proto-Indo-European and Proto Afroasiatic

TOWARD PROTO-NOSTRATIC -- Editorial page -- Title page -- Copyright page -- FOREWORD -- PREFACE -- Table of contents -- 1. INTRODUCTION -- 1.1. PREFATORY REMARKS -- 1.2. THE INDO-EUROPEAN LANGUAGES -- 1.3. THE AFROASIATIC LANGUAGES -- 2.
Bomhard, Alan R., Hopper, Paul J.
core  

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

The Sustainability of University-Business Innovation Clusters: The Case of IoT Rapid-Proto Labs [PDF]

, 2020
The objective of this study is to identify sources of support for the IoT Rapid-Proto Labs to enable the success and sustainability of the project. This study is done for the European transnational multidisciplinary project IoT Rapid-Proto Labs, which ...
Lindberg, Christa
core  

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

Beyond the 2nd Messenger - Oncogenes and Transcription Factors

, 1988
Neoplasia is the consequence of a breakdown in the mechanisms responsible for the regulation of cell growth and development. The cancer cell either fails to respond or responds inappropriately to environmental cues.
Curran, T., Rauscher, F. J., Franza, B. R., Cohen, D. R.   +3 more
core   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Biología del cáncer

Correo Científico Médico, 2019
El cáncer constituye un problema de salud con gran impacto humano y económico. La mortalidad por cáncer ha aumentado sostenidamente en los últimos 25 años a nivel mundial.
Alejandro Bermúdez Garcell, Nilvia Bienvenida Serrano Gámez, Rolando Teruel Ginés, María de los Ángeles Leyva Montero, Anthony Alfonso Naranjo Coronel   +4 more
doaj   +2 more sources

La trasparenza nei rapporti banca-cliente

Analisi della regolamentazione relativa alla trasparenza bancaria: strumenti di pubblicità, forma e contenuto dei contratti, variazione unilaterale delle condizioni economiche, modalità di calcolo degli interessi e requisiti organizzativi, con ...
Proto Antonio
core  

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source