Results 111 to 120 of about 325,026 (325)
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia
npj Precision OncologyAcute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes.
Ashlee Thomson +4 more
doaj +1 more source
Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7)
HeliyonUbiquitin-specific protease7 (USP7) regulates the stability of the p53 tumor suppressor protein and several other proteins critical for tumor cell survival.
Seema Zadi +6 more
doaj +1 more source
, 2018 Communication weaves the connections between new spatial relations, and creates new meanings and new imaginaries. The contemporary process of communication is giving substance to a model of society which identifies itself in the vast multimedia sea where
Albanese V., Greco V., Proto M. +3 more
core
Beyond the 2nd Messenger - Oncogenes and Transcription Factors
, 1988 Neoplasia is the consequence of a breakdown in the mechanisms responsible for the regulation of cell growth and development. The cancer cell either fails to respond or responds inappropriately to environmental cues.
Curran, T. +3 more
core +1 more source
Advanced Science, EarlyView.AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li +6 more
wiley +1 more source
Proto-Institutions to Open Government: (In)forming Publics with the Transparency We Deserve
, 2021 Proto-Institutions to Open Government: (In)forming Publics with the Transparency We ...
Luke Heemsbergen (13081137)
core
Advanced Science, EarlyView.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng +14 more
wiley +1 more source
The loss of *g before *m in Proto-Slavic
, 2010 This paper proposes a new sound rule for Proto-Slavic, according to which *g (from PIE *g, *gw, *gh, and *gwh) was lost before *m. This development was posterior to Winter’s law and the merger of voiced and aspirated stop in Slavic.
Matasović, Ranko, Ranko Matasović
core
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source