Results 1 to 10 of about 14,853 (233)

Expression of the Human Serotonin 5-HT₇ Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model

Cells, 2022
Gliomas are the most common primary brain tumors in adults. Significant progress has been made in recent years in identifying the molecular alterations involved in gliomas.
Florestan Courant, Marion Maravat, Wanyin Chen, David Gosset, Lauren Blot, Nadège Hervouet-Coste, Vincent Sarou-Kanian, Séverine Morisset-Lopez, Martine Decoville   +8 more
doaj   +1 more source

LINFOMA DE ZONA MARGINAL (MALT) EM GLÂNDULA LACRIMAL - UM RELATO DE CASO

Hematology, Transfusion and Cell Therapy, 2023
Objetivos: O propósito deste estudo é divulgar os conhecimentos sobre um caso raro de linfoma de zona marginal (MALT) em glândula lacrimal, visando ampliar o conhecimento sobre essa doença no meio científico.
PC Gontijo, MMM Zarife, MGT Carvalho, LCM Peixoto, L Alves, MC Piancastelli, MAS Ullmann   +6 more
doaj   +1 more source

ANÁLISE COMPREENSIVA DO GENE HCK EM NEOPLASIAS MIELOIDES: PERSPECTIVAS EM FUNÇÕES BIOLÓGICAS, PROGNÓSTICO E RESPOSTA À AGENTES ANTINEOPLÁSICOS

Hematology, Transfusion and Cell Therapy, 2023
Objetivos: As neoplasias mieloides são resultantes de alterações moleculares na célula-tronco hematopoiética, sendo a leucemia mieloide aguda (LMA) a mais agressiva e com piores desfechos clínicos.
MFL Carvalho, BO Almeida, MLP Bueno, HP Vicari, K Lima, EM Rego, FM Roversi, JA Machado-Neto   +7 more
doaj   +1 more source

Cell Type-specific Expression of the Mas Proto-oncogene in Testis [PDF]

Journal of Histochemistry & Cytochemistry, 2002
The Mas proto-oncogene encodes a G-protein-coupled receptor with the common seven transmembrane domains and may be involved in the actions of angiotensins. Because Mas is highly expressed in testis, we investigated the cell type-specificity and the onset of expression of the gene in this organ.
Natalia, Alenina, Tatjana, Baranova, Eugene, Smirnow, Michael, Bader, Andrea, Lippoldt, Eugene, Patkin, Thomas, Walther   +6 more
openaire   +2 more sources

TheMASProto-Oncogene Is Not Imprinted in Humans [PDF]

Genomics, 1996
Recently it was shown that the murine Mas gene, which is located less than 300 kb from the imprinted Igf2r gene, is also imprinted in Day 11.5 embryos with expression exclusively from the paternal allele. We have assigned the human MAS gene to chromosomal bands 6q25.3-q26 in close proximity to the IGF2R gene.
Riesewijk, A., Schepens, M., Mariman, E., Ropers, H., Kalscheuer, V.   +4 more
openaire   +4 more sources

Expression of the mouse and rat mas proto‐oncogene in the brain and peripheral tissues [PDF]

FEBS Letters, 1995
We isolated the mas proto‐oncogene from a mouse genomic library. Sequence analysis showed that it contains an open reading frame without intervening sequences. The amino acid sequence deduced confirms the seven‐transmembrane‐domain structure and exhibits 97% and 91% amino acid homology with the rat and the human Mas, respectively. In mice and rats, mas
Metzger, Rainer, Bader, Michael, Ludwig, Thomas, Berberich, Christof, Bunnemann, Bernd, Ganten, Detlev   +5 more
openaire   +2 more sources

Up-regulation of the Angiotensin II Type 1 Receptor by the MAS Proto-oncogene Is Due to Constitutive Activation of Gq/G11 by MAS [PDF]

Journal of Biological Chemistry, 2006
Coexpression of the MAS proto-oncogene with the angiotensin II type 1 (AT(1)) receptor in CHO-K1 cells has been reported to increase the number of [(3)H]angiotensin II-binding sites, although MAS does not bind [(3)H]angiotensin II. In HEK293 cells stably expressing AT(1) receptor-cyan fluorescent protein (CFP), MAS-yellow fluorescent protein (YFP ...
Meritxell, Canals, Laura, Jenkins, Elaine, Kellett, Graeme, Milligan   +3 more
openaire   +2 more sources

Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype. [PDF]

, 1996
It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome.
Deckart, H. F., Dralle, H., Frank-Raue, K., Frilling, A., Haase, R., Hampel, R., Höppner, W., Kirchner, R., Klempa, J., Kotzerke, J., Mann, K., Raue, F., Rendl, J., Ritter, M. M., Scholz, G. H., Seif, F.   +15 more
core   +1 more source

BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer [PDF]

, 2009
Structural chromosome aberrations are known hallmarks of many solid tumors. In the papillary form of thyroid cancer (PTC), for example, activation of the receptor tyrosine kinase (RTK) genes, RET and neurotrophic tyrosine kinase receptor type I (NTRK1)
Baumgartner, Adolf, Kwan, Johnson, Lu, Chun-Mei, Wang, Mei, Weier, Heinz-Ulrich G., Weier, Jingly F., Zitzelsberger, Horst F.   +6 more
core   +2 more sources

Mutations and amplification of oncogenes in endometrial cancer [PDF]

, 1999
Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
An, Han-Xiang, Beckmann, Matthias W., Bender, Hans G., Cho, Yong-Jig, Hantschmann, Peer, Niederacher, Dieter   +5 more
core   +1 more source