Results 11 to 20 of about 8,187 (229)

Proto-Oncogene Mas [PDF]

, 2020
openaire   +2 more sources

Angiotensin‐(1‐7) and Obesity: Role in Cardiorespiratory Fitness and COVID‐19 Implications [PDF]

, 2020
We have read with interest the recent review by Zbinden-Foncea et al. suggesting that high levels of cardiorespiratory fitness induced by prior exercise training may confer some innate immune protection against coronavirus disease (COVID-19) by ...
Robson A. S. Santos, Sérgio Henrique Sousa Santos, Daisy Motta‐Santos, Robson Augusto Souza dos Santos, Daisy Motta Santos   +4 more
core   +1 more source

Black Chokeberry (Aronia melanocarpa) Juice Supplementation Affects Age-Related Myocardial Remodeling in Rats

Life
Background: Cardiac aging is associated with myocardial remodeling and reduced angiogenesis. Counteracting these changes with natural products is a preventive strategy with great potential.
Elena Daskalova, Mina Pencheva, Slavi Delchev, Lyudmila Vladimirova-Kitova, Spas Kitov, Stoyan Markov, David Baruh, Petko Denev   +7 more
doaj   +1 more source

Neoplasias endocrinas múltiples: de lo molecular a lo clínico

Revista Médica Clínica Las Condes
Resumen: Las neoplasias endocrinas múltiples (NEM) tipo 1, 2 (se subdivide en 2A y 2B), 4 y 5; constituyen síndromes genéticos hereditarios con un patrón de transmisión autosómico dominante.
Nelson Wohllk, MD, Consuelo Olave, MD
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mas Oncogene Signaling and Transformation Require the Small GTP-Binding Protein Rac

, 1998
The Mas oncogene encodes a novel G-protein-coupled receptor that was identified originally as a transforming protein when overexpressed in NIH 3T3 cells. The mechanism and signaling pathways that mediate Mas transformation have not been determined.
Westwick, John K., Chrzanowska-Wodnicka, Magdalena, Symons, Marc, Der, Channing J., Zohn, Irene E.   +4 more
core   +1 more source

Intestinal Microbiota and Gene Expression Alterations in Chinese Mitten Crab (Eriocheir sinensis) Under Deltamethrin Exposure

Antioxidants
The intestine is an important immune organ of aquatic animals and it plays an essential role in maintaining body health and anti-oxidative stress. To investigate the toxic effects of deltamethrin in intestinal tissue of Chinese mitten crabs (Eriocheir ...
Chunyi Zhong, Jinliang Du, Haojun Zhu, Jiancao Gao, Gangchun Xu, Pao Xu   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source