Results 91 to 100 of about 263,760 (324)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Role of DNA methylation in cancer development and its clinical applications

Clinical and Translational Discovery
methyltransferase gene (DNA) methylation is a key process in epigenetic modification. This transformation leads to genomic instability that creates an impact on gene expression.
Swarup Sonar, Sidhanti Nyahatkar, Ketki Kalele, Manab Deb Adhikari   +3 more
doaj   +1 more source

Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review) [PDF]

Саратовский научно-медицинский журнал, 2011
The research work presents an analysis of literature review and results of investigations on the problems of etiology, pathogenesis, classification and peculiarities of clinical manifestations of chronic lymphocytic leukaemia.
Chesnokova N.P., Shelekhova T.V., Zhevak T.N.   +2 more
doaj  

Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes. [PDF]

Cancers (Basel), 2023
Alqahtani T, Kumarasamy V, Alghamdi SS, Suliman RS, Bin Saleh K, Alrashed MA, Aldhaeefi M, Sun D.   +7 more
europepmc   +1 more source

Nucleic acid technology and infectious diseases [PDF]

, 1997
The past decade has witnessed an explosion in the knowledge of microbial genetics, pathogenesis, and antimicrobial resistance as a result of advances in molecular technology.
Luk, WK, Wong, SSY, Woo, PCY, Yuen, KY
core  

Lymphoma caused by intestinal microbiota. [PDF]

, 2014
The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions ...
Schiestl, Robert H, Yamamoto, Mitsuko L
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model

Bulletin of the National Research Centre
Background The second most common cancer in the world is breast cancer. Chemotherapy is used to treat breast cancer, but instances of multidrug resistance, targets that are not selective, and physicochemical issues raise doubts about its efficacy.
Aida I. El makawy, Sekena H. Abdel-Aziem, Shaimaa E. Mohammed, Faten M. Ibrahim, Heba A. Abd EL-Kader, Hafiza A. Sharaf, Dalia A. Youssef, Dalia M. Mabrouk   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Aneuploidías del cromosoma 17 y deleción del Gen TP53 en neoplasias hematológicas

Iatreia, 2006
La oncogénesis es considerada un proceo de múltiples etapas, en donde los factores genéticos son esenciales para su origen y desarrollo; se afectan principalmente dos grandes grupos de genes; se afectan principalmente dos grandes grupos de genes: los ...
Carlos Mario Muñetón Peña, José Luis Ramírez Castro, Gonzálo Vásquez Palacio, Gloria Ramírez Gaviria, Luis Fernando Isaza Jiménez, Juan Carlos Herrera Patiño   +5 more
doaj