Results 51 to 60 of about 111,107 (240)

Potential malignant transformation in the gastric mucosa of immunodeficient mice with persistent Mycoplasma penetrans infection. [PDF]

PLoS ONE, 2017
Mycoplasma infection has been reported in immunocompromised cancer patients; nevertheless, it is not clear if persistent Mycoplasma infection could facilitate the proliferation of cancer cells in immunocompromised organisms.
Shuyan Cao, Dandan Shen, Yadong Wang, Linxi Li, Liping Zhou, Yuxue Wang   +5 more
doaj   +1 more source

Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring

, 2022
Polyploid cells demonstrate biological plasticity and stress adaptation in evolution; development; and pathologies, including cardiovascular diseases, neurodegeneration, and cancer.
Vinogradov, Alexander E., Olga V. Anatskaya, Alexander E. Vinogradov, Anatskaya, Olga V.   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Gastrointestinal stromal tumor of the stomach. Case report

Revista Médica del Hospital General de México, 2018
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the alimentary tract. Nowadays GISTs represents 0.1–3% of all gastrointestinal malignancies, making it a diagnostic challenge.
P.R. Arellano-López, R. Solalinde-Vargas, J.I. Guzmán-Mejía, L.G. González-Pérez, A.C. Zamora-García   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MECANISMOS FISIOPATOLÓGICOS EM NEOPLASIAS CUTÂNEAS RARAS: A INFLUÊNCIA DOS PROTO-ONCOGENES NO MELANOMA ACRAL E CARCINOMAS DE CÉLULAS DE MERKEL [PDF]

Introdução: As neoplasias cutâneas raras, como o melanoma acral e o carcinoma de células de Merkel, representam desafios significativos no campo da oncologia devido à sua agressividade e baixa incidência.
Fechine Honorato, Pedro, Perez Molan, Marina, Rocha, Isleanne Pereira, Sousa, Maria Victória Alves Lima de, Peixoto Mariano , Bruna, Dalla Bernardina , Livia, Moura Teixeira , Pedro Henrique, Segadilha Prado , Douglas, Freitas , Paloma de Carvalho, Ribeiro de Freitas , Matheus Buissa   +9 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Global real-time quantification/reverse transcription-polymerase chain reaction for detecting proto-oncogenes associated with 14q32 chromosomal translocation in multiple myeloma

Haematologica, 2005
A global real-time quantitative/reverse transcription-polymerase chain reaction technique for detecting the expression of six 14q32 chromosomal translocation-associated proto-oncogenes in marrow plasma cells was established and applied to myeloma ...
E Tajima, M Uranishi, S Iida, H Komatsu, M Nitta, R Ueda   +5 more
doaj  

Abstract 1023: Activation of proto-oncogenes by enhancer-hijacking in high-risk neuroblastoma

, 2017
Background: Neuroblastoma (NB), a neural crest-derived tumor of the sympathetic nervous system, is the most common extracranial solid tumor in children.
Stefan Gröschel, Umut Toprak, Daniel Dreidax, Kai-Oliver Henrich, Sebastian Steinhauser, Ron Schwessinger, Nati Ha, Dilafruz Juraeva, Moritz Gartlgruber, Martin Peifer, Matthias Schlesner, Young-Gyu Park, Frank Westermann, Larisa Savelyeva, Matthias Fischer, Benedikt Brors, Carl Herrmann   +16 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source