Results 41 to 50 of about 30,889 (150)
Advances in Molecular Research of Oncogenes [PDF]
, 2023 The isolation of the first human oncogene (HRAS), a critical breakthrough in cancer research, has occurred over forty years ago, and the identification of new pathogenic oncogenes has continuously grown since [...
Baltanás, Fernando C. +5 more
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Oncogenes and anti-oncogenes in tumorigenesis [PDF]
Reproduction Nutrition Développement, 1990 Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences.
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Cancer Research, 2008 Abstract Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called “oncogene addiction,” provides a rationale for molecular targeted therapy.
I Bernard, Weinstein, Andrew, Joe
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Reviewing Oncogenes and Proto-Oncogenes
International Journal of Scientific Research in Science and Technology, 2021 This article is an examination of the Reviewing oncogenes and Proto-oncogenes The scientific development and subsequent “oncogenes and Proto-oncogenes” continues to influence the researchers all over the globe today. This article examines the research done and published by researchers and scientists.
Batra, Nehal +3 more
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Oncogene, 2003 Transformation of normal melanocytes into melanoma cells is accomplished by the activation of growth stimulatory pathways, typically leading to cellular proliferation, and the inactivation of apoptotic and tumor suppressor pathways. Small molecule inhibitors of proteins in the growth stimulatory pathways are under active investigation, and their ...
David, Polsky, Carlos, Cordon-Cardo
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Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis [PDF]
, 2004 Background Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes.
Abouna, Sylvie +11 more
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Biomedicines, 2021 Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease caused in 10% of cases by inherited mutations considered “familial”. An ever-increasing amount of evidence is showing a fundamental role for RNA metabolism in ALS pathogenesis,
Federica Rey +8 more
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Distribution of oncogenes and tumor suppressors with cancer-specific alternative splicing in cancer.
, 2013 Blue squares indicate oncogenes, red squares indicate tumor suppressors, and yellow squares show both oncogenes and tumor suppressors.
Chunjiang He (374122) +4 more
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Frontiers in GeneticsIn this study, we report the mutational profiles, pathogenicity, and their association with different clinicopathologic and sociogenetic factors in patients with Pashtun ethnicity for the first time. A total of 19 FFPE blocks of invasive ductal carcinoma
Hilal Ahmad +12 more
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What makes oncogenes mutually exclusive?
, 2017 Cancer is driven by mutations in genes whose products participate in major signaling pathways that fuel cell proliferation and survival. It is easy to assume that the more of these so-called driver mutations a tumor accumulates, the faster it progresses.
Bergo, MO, Cisowski, J
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