Results 1 to 10 of about 485,635 (291)

The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration [PDF]

eLife, 2015
The control of proliferation and differentiation by tumor suppressor genes suggests that evolution of divergent tumor suppressor repertoires could influence species’ regenerative capacity.
Robert G Hesse, Gayle K Kouklis, Nadav Ahituv, Jason H Pomerantz   +3 more
doaj   +3 more sources

p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes [PDF]

Cell Death Discovery
The transcription factor regulatory factor X 7 (RFX7) has been identified as a tumor suppressor that is recurrently mutated in lymphoid cancers and appears to be dysregulated in many other cancers. RFX7 is activated by the well-known tumor suppressor p53
Katjana Schwab, Konstantin Riege, Luis Coronel, Clara Stanko, Silke Förste, Steve Hoffmann, Martin Fischer   +6 more
doaj   +2 more sources

Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma [PDF]

Liver Research, 2021
Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.
Fang Wang, Peter Breslin S J, Wei Qiu
doaj   +2 more sources

Tumor suppressor genes in the tumor microenvironment [PDF]

Disease Models & Mechanisms
Bahareh Tabanifar, Hannah Lau, Kanaga Sabapathy   +2 more
doaj   +2 more sources

Integrative Genomic and Transcriptomic Analyses of Tumor Suppressor Genes and Their Role on Tumor Microenvironment and Immunity in Lung Squamous Cell Carcinoma

Frontiers in Immunology, 2021
Non-small-cell lung cancers (NSCLCs) are largely classified into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), which have different therapeutic options according to its molecular profiles and immune checkpoint expression, especially
Ahreum Kim, Ahreum Kim, Sun Min Lim, Joo-Hang Kim, Joo-Hang Kim, Jeong-Sun Seo, Jeong-Sun Seo   +6 more
doaj   +1 more source

Synthetic lethal approaches to target cancers with loss of PTEN function

Genes and Diseases, 2023
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2).
Ayse Ertay, Rob M. Ewing, Yihua Wang
doaj   +1 more source

Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. [PDF]

, 2016
Prostate carcinogenesis involves alterations in several signaling pathways, the most prominent being the PI3K/AKT pathway. This pathway is constitutively active and drives prostate cancer (PCa) progression to advanced metastatic disease. PTEN, a critical
Chowdhary, Harshika, Colden, Melissa, Dahiya, Rajvir, Dar, Altaf A, Dasgupta, Pritha, Deng, Guoren, Greene, Kirsten, Hashimoto, Yutaka, Imai-Sumida, Mitsuho, Kato, Taku, Kulkarni, Priyanka, Majid, Shahana, Mitsui, Yozo, Nip, Hannah, Saini, Sharanjot, Shiina, Marisa, Tabatabai, Z Laura, Tanaka, Yuichiro, Varahram, Shahryari, Yamamura, Soichiro   +19 more
core   +17 more sources

The Role of Epstein-Barr Virus in Modulating Key Tumor Suppressor Genes in Associated Malignancies: Epigenetics, Transcriptional, and Post-Translational Modifications

Biomolecules, 2022
Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti, Michael Bright Yakass, Ernest Adjei Okertchiri, Samuel Mawuli Adadey, Osbourne Quaye   +4 more
doaj   +1 more source

Genome-wide screening of tumor suppressor genes in oncogenic transformation of normal lung epithelial cells and preliminary validation in sample databases

Di-san junyi daxue xuebao, 2022
Objective To identify new human lung cancer suppressors in a genome-wide screening library during neoplastic transformation of normal human lung epithelial cells using CRISPR/Cas9-mediated genome editing, and preliminarily validate the Results in non ...
ZHAO Binyu, ZHANG Junlei, WANG Jiaqi, RUAN Yan, ZHANG Yue, LIU Lianlian   +5 more
doaj   +1 more source

Molecular Genetics of Esophageal Cancer : Indian Perspective

Asian Pacific Journal of Cancer Biology, 2021
Background: RIZ1 is one of the tumor-suppressor genes that is silenced in many human cancers. Change in RIZ1 expression has not been reported in ESCC patients.
Suddhasattwa Ray, Mona Malekzadehmoghani, Sonia S Ray, Partha Sen, Sayan Chakraborty   +4 more
doaj   +1 more source