Results 1 to 10 of about 334,170 (216)

p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes [PDF]

Cell Death Discovery
The transcription factor regulatory factor X 7 (RFX7) has been identified as a tumor suppressor that is recurrently mutated in lymphoid cancers and appears to be dysregulated in many other cancers. RFX7 is activated by the well-known tumor suppressor p53
Katjana Schwab, Konstantin Riege, Luis Coronel, Clara Stanko, Silke Förste, Steve Hoffmann, Martin Fischer   +6 more
doaj   +2 more sources

Tumor suppressor genes in the tumor microenvironment [PDF]

Disease Models & Mechanisms
Bahareh Tabanifar, Hannah Lau, Kanaga Sabapathy   +2 more
doaj   +2 more sources

Aumolertinib with carboplatin–pemetrexed versus aumolertinib for nonsmall cell lung cancer with EGFR and concomitant tumor suppressor genes (ACROSS2): An open‐label, multicenter, randomized phase 3 study [PDF]

Ca-A Cancer Journal for Clinicians
Da-Xing Zhu
exaly   +2 more sources

Integrative Genomic and Transcriptomic Analyses of Tumor Suppressor Genes and Their Role on Tumor Microenvironment and Immunity in Lung Squamous Cell Carcinoma

Frontiers in Immunology, 2021
Non-small-cell lung cancers (NSCLCs) are largely classified into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), which have different therapeutic options according to its molecular profiles and immune checkpoint expression, especially
Ahreum Kim, Ahreum Kim, Sun Min Lim, Joo-Hang Kim, Joo-Hang Kim, Jeong-Sun Seo, Jeong-Sun Seo   +6 more
doaj   +1 more source

Synthetic lethal approaches to target cancers with loss of PTEN function

Genes and Diseases, 2023
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2).
Ayse Ertay, Rob M. Ewing, Yihua Wang
doaj   +1 more source

The Role of Epstein-Barr Virus in Modulating Key Tumor Suppressor Genes in Associated Malignancies: Epigenetics, Transcriptional, and Post-Translational Modifications

Biomolecules, 2022
Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti, Michael Bright Yakass, Ernest Adjei Okertchiri, Samuel Mawuli Adadey, Osbourne Quaye   +4 more
doaj   +1 more source

Genome-wide screening of tumor suppressor genes in oncogenic transformation of normal lung epithelial cells and preliminary validation in sample databases

Di-san junyi daxue xuebao, 2022
Objective To identify new human lung cancer suppressors in a genome-wide screening library during neoplastic transformation of normal human lung epithelial cells using CRISPR/Cas9-mediated genome editing, and preliminarily validate the Results in non ...
ZHAO Binyu, ZHANG Junlei, WANG Jiaqi, RUAN Yan, ZHANG Yue, LIU Lianlian   +5 more
doaj   +1 more source

Molecular Genetics of Esophageal Cancer : Indian Perspective

Asian Pacific Journal of Cancer Biology, 2021
Background: RIZ1 is one of the tumor-suppressor genes that is silenced in many human cancers. Change in RIZ1 expression has not been reported in ESCC patients.
Suddhasattwa Ray, Mona Malekzadehmoghani, Sonia S Ray, Partha Sen, Sayan Chakraborty   +4 more
doaj   +1 more source

Retinoblastoma Protein Paralogs and Tumor Suppression

Frontiers in Genetics, 2022
The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
doaj   +1 more source

Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review

Iranian Journal of Public Health, 2021
Background: The tumor suppressor genes play a critical role in cellular and molecular mechanisms such as cell cycle processes, cell differentiation and apoptosis.
Sara Sheikkholeslami, Marjan Zarif -Yeganeh, Samaneh Farashi, Fereidoun Azizi, Sima Kheradmand Kia, Ladan Teimoori-Toolabi, Mehdi Hedayati   +6 more
doaj   +1 more source