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Tumor suppressor genes in the tumor microenvironment [PDF]
Disease Models & MechanismsABSTRACT Tumor suppressor genes (TSGs) are thought to suppress tumor development primarily via cancer cell-autonomous mechanisms. However, the tumor microenvironment (TME) also significantly influences tumorigenesis. In this context, a role for TSGs in the various cell types of the TME in regulating tumor growth is emerging.
Bahareh Tabanifar +2 more
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Oncogenes and Tumor Suppressor Genes [PDF]
Acta Oncológica, 1988 The artificial selection of the directly acting or acute RNA tumor viruses for high transforming ability has led to the isolation of defective retroviral genomes that have picked up, by accidental recombination, some of the important genes that influence, trigger or regulate cell division.
Georg Klein
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Oncogenes and tumor suppressor genes
Ca-A Cancer Journal for Clinicians, 1994 In the past 15 years, many of the mechanisms underlying the molecular origins of cancer have been uncovered, and a clear picture of the role of oncogenes and tumor suppressor genes in carcinogenesis has developed. This article reviews the mechanisms by which oncogenes and tumor suppressor genes participate in the creation of tumors.
Robert A Weinberg
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p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes [PDF]
Cell Death DiscoveryThe transcription factor regulatory factor X 7 (RFX7) has been identified as a tumor suppressor that is recurrently mutated in lymphoid cancers and appears to be dysregulated in many other cancers. RFX7 is activated by the well-known tumor suppressor p53
Katjana Schwab +6 more
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Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma [PDF]
Liver Research, 2021 Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.
Fang Wang, Peter Breslin S J, Wei Qiu
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Integrated transcriptome interactome study of oncogenes and tumor suppressor genes in breast cancer
Genes and Diseases, 2019 Breast cancer is the leading cause for mortality among women worldwide. Dysregulation of oncogenes and tumor suppressor genes is the major reason for the cause of cancer.
G. Pranavathiyani +3 more
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Aumolertinib with carboplatin–pemetrexed versus aumolertinib for nonsmall cell lung cancer with EGFR and concomitant tumor suppressor genes (ACROSS2): An open‐label, multicenter, randomized phase 3 study [PDF]
Ca-A Cancer Journal for CliniciansDa-Xing Zhu
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Frontiers in Immunology, 2021 Non-small-cell lung cancers (NSCLCs) are largely classified into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), which have different therapeutic options according to its molecular profiles and immune checkpoint expression, especially
Ahreum Kim +6 more
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Synthetic lethal approaches to target cancers with loss of PTEN function
Genes and Diseases, 2023 Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2).
Ayse Ertay, Rob M. Ewing, Yihua Wang
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Biomolecules, 2022 Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti +4 more
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