Results 41 to 50 of about 3,321,094 (294)

Gene expression array analysis to identify candidate tumor suppressor genes in melanoma [PDF]

, 2017
Melanoma is a complex multifactorial disease; therefore, a combination of various approaches is necessary to girt all aspects of its biology and identify the many different genes and factors involved in its etiology.Epigenetic regulation of tumor ...
Stark, Mitchell S., Bonazzi, Vanessa F., Mitchell S. Stark, Vanessa F. Bonazzi   +3 more
core   +1 more source

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone

Advanced Science, 2022
Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination
Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Yian Wang, Charles R. Myers, Bryon D. Johnson, Micael Hardy, Balaraman Kalyanaraman, Ming You   +9 more
doaj   +1 more source

BECN1 and BRCA1 Deficiency Sensitizes Ovarian Cancer to Platinum Therapy and Confers Better Prognosis

Biomedicines, 2021
Background: BRCA1, BECN1 and TP53 are three tumor suppressor genes located on chromosome 17 and frequently found deleted, silenced, or mutated in many cancers.
Amreen Salwa, Alessandra Ferraresi, Menaka Chinthakindi, Letizia Vallino, Chiara Vidoni, Danny N. Dhanasekaran, Ciro Isidoro   +6 more
doaj   +1 more source

The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H2

Biomolecules
The transcription factor E2F1 is the principal target of the tumor suppressor pRB. E2F1 promotes cell proliferation by activating growth-promoting genes upon growth stimulation.
Lin Zhao, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Yuki Kamiya, Hiroyuki Toh, Hideyuki Komori, Ritsuko Iwanaga, Andrew P. Bradford, Hideo Nishitani, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani   +13 more
doaj   +1 more source

Tumor-suppressor-oncogene-scores (TSOS).

, 2018
(a) Enrichment analysis using expression derived tumor-suppressor-oncogene-score (TSOS) in human tumors microarray and TCGA/GTEx RNAseq datasets for the whole candidate ortholog gene set (n = 619 and n = 637 respectively) in 1 million random samplings ...
Helena E. Richardson (434920), Shane J. F. Cronin (5859743), Lee Willoughby (5859722), Patrick O. Humbert (136871), Andreas Wernitznig (731157), Constantine S. Mitsiades (348466), Sofya Golenkina (5859731), Susanne Gruber (5859737), Ricardo Matos de Simoes (5859725), G. Gregory Neely (113800), Jan Manent (5859719), Elisabeth Eva Kanitz (368265), Kaylene J. Simpson (146322), Josef M. Penninger (113854), Tamara Zoranovic (5859716), John E. La Marca (5859728), Belinda Angjeli (5859740), Xia Cuiping (5859734)   +17 more
core   +1 more source

The Effect of 5-Aza-2′-Deoxycytidine in Combination to and in Comparison with Vorinostat on DNA Methyltransferases, Histone Deacetylase 1, Glutathione S-Transferase 1 and Suppressor of Cytokine Signaling 1 Genes Expression, Cell Growth Inhibition and Apop

International Journal of Hematology-Oncology and Stem Cell Research, 2020
Background: Aberrant methylation and histone deacetylation of tumor suppressor genes (TSGs) are the most epigenetic alterations involving in tumorigenesis.
Masumeh Sanaei, Fraidoon Kavoosi, Zahra Esmi   +2 more
doaj   +1 more source

Oncogenes and Tumor Suppressor Genes [PDF]

Acta Oncologica, 1988
The artificial selection of the directly acting or acute RNA tumor viruses for high transforming ability has led to the isolation of defective retroviral genomes that have picked up, by accidental recombination, some of the important genes that influence, trigger or regulate cell division.
openaire   +2 more sources

Tumor suppressor genes in myeloid differentiation and leukemogenesis

, 2009
Tumor suppressor genes, such as p53, RB, the INK4-ARF family and PML, suppress malignant transformation by regulating cell cycle progression, ensuring the fidelity of DNA replication and chromosomal segregation, or by inducing apoptosis in response to ...
Britschgi, Christian, Fey, Martin F, Fey MF, Britschgi C, Fey, Martin   +4 more
core   +1 more source

Transcriptional responses of tumor cell lines to interferon-alpha [PDF]

, 2013
Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core   +1 more source

Breast Cancer Stem Cells and Tumor Suppressor Genes

Journal of the Formosan Medical Association, 2008
Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to be fully addressed. The molecular distinction between normal and cancerous breast stem cells is not clear.
Wendy W. Hwang-Verslues, King-Jen Chang, Eva Y.-H.P. Lee, Wen-Hwa Lee   +3 more
doaj   +1 more source