Results 41 to 50 of about 485,635 (291)

Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells

Journal of Experimental & Clinical Cancer Research, 2011
Background DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer.
Li Ti-yuan, Zhou Shu-yan, Sun Ye-hong, Chen Fu-qiang, Zhang Yi, Chen Rui   +5 more
doaj   +1 more source

Identifying genes with tri-modal association with survival and tumor grade in cancer patients

BMC Bioinformatics, 2019
Background Previous cancer genomics studies focused on searching for novel oncogenes and tumor suppressor genes whose abundance is positively or negatively correlated with end-point observation, such as survival or tumor grade.
Minzhe Zhang, Tao Wang, Rosa Sirianni, Philip W. Shaul, Yang Xie   +4 more
doaj   +1 more source

Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing [PDF]

, 2010
Background To identify potential tumor suppressor genes, genome-wide data from exome and transcriptome sequencing were combined to search for genes with loss of heterozygosity and allele-specific expression.
Qi Zhao, Ewen F Kirkness, Otavia L Caballero, Pedro A Galante, Raphael B Parmigiani, Lee Edsall, Samantha Kuan, Zhen Ye, Samuel Levy, Ana Tereza R Vasconcelos, Bing Ren, Sandro J de Souza, Anamaria A Camargo, Andrew JG Simpson, Robert L Strausberg   +14 more
core   +2 more sources

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin. [PDF]

PLoS ONE, 2014
The RNA-binding protein Tristetraprolin (TTP, ZFP36) functions as a tumor suppressor that impairs the development and disables the maintenance of MYC-driven lymphoma.
Mohammad Fallahi, Antonio L Amelio, John L Cleveland, Robert J Rounbehler   +3 more
doaj   +1 more source

Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer [PDF]

, 2018
Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer.
Fatica, Alessandro, Morlando, Mariangela
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Integrated transcriptome interactome study of oncogenes and tumor suppressor genes in breast cancer

Genes and Diseases, 2019
Breast cancer is the leading cause for mortality among women worldwide. Dysregulation of oncogenes and tumor suppressor genes is the major reason for the cause of cancer.
G. Pranavathiyani, Raja Rajeswary Thanmalagan, Naorem Leimarembi Devi, Amouda Venkatesan   +3 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

The role of oxidative stress-related genes in idiopathic pulmonary fibrosis

Scientific Reports
Idiopathic pulmonary fibrosis (IPF) is an age-related interstitial lung disease of unknown cause. Oxidative stress, an imbalance between oxidants and antioxidants, is implicated in IPF pathogenesis and prognosis but needs further study.
Wenfei Zhao, Bing Bai, Hongyun Li, Yonghai Feng, Jun Sun, Yang Fang, Pengyuan Zheng, Guojun Zhang   +7 more
doaj   +1 more source