Results 31 to 40 of about 3,086,863 (251)
Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
Liver Research, 2021 Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.
Fang Wang, Peter Breslin S J, Wei Qiu
doaj +1 more source
International Journal of Hematology-Oncology and Stem Cell Research, 2020 Background: Aberrant methylation and histone deacetylation of tumor suppressor genes (TSGs) are the most epigenetic alterations involving in tumorigenesis.
Masumeh Sanaei +2 more
doaj +1 more source
Tumor suppressor genes in myeloid differentiation and leukemogenesis
, 2009 Tumor suppressor genes, such as p53, RB, the INK4-ARF family and PML, suppress malignant transformation by regulating cell cycle progression, ensuring the fidelity of DNA replication and chromosomal segregation, or by inducing apoptosis in response to ...
Britschgi, Christian, Fey, Martin F
core +1 more source
Gene expression array analysis to identify candidate tumor suppressor genes in melanoma [PDF]
, 2017 Melanoma is a complex multifactorial disease; therefore, a combination of various approaches is necessary to girt all aspects of its biology and identify the many different genes and factors involved in its etiology.Epigenetic regulation of tumor ...
Stark, Mitchell S. +3 more
core +1 more source
A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins. [PDF]
, 2010 Background Peroxide turnover and signalling are involved in many biological phenomena relevant to human diseases. Yet, all the players and mechanisms involved in peroxide perception are not known.
Muszewska, Anna +5 more
core +2 more sources
Tumor-suppressor-oncogene-scores (TSOS).
, 2018 (a) Enrichment analysis using expression derived tumor-suppressor-oncogene-score (TSOS) in human tumors microarray and TCGA/GTEx RNAseq datasets for the whole candidate ortholog gene set (n = 619 and n = 637 respectively) in 1 million random samplings ...
Helena E. Richardson (434920) +17 more
core +1 more source
Breast Cancer Stem Cells and Tumor Suppressor Genes
Journal of the Formosan Medical Association, 2008 Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to be fully addressed. The molecular distinction between normal and cancerous breast stem cells is not clear.
Wendy W. Hwang-Verslues +3 more
doaj +1 more source
The role of the tumor suppressor CYLD in Yersinia enterocolitica infection [PDF]
, 2012 Recent studies have identified the tumor suppressor CYLD as a key regulator of NF -κB, a transcription factor that promotes cell survival and oncogenesis, as well as host defence to infection.
Liu, Yunying
core +1 more source
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G. +5 more
core +1 more source
This chapter describes tumor suppressor genes. It emphasizes that the human body has mechanisms exerted by tumor suppressor genes that normally “police” the processes that regulate cell numbers and ensure that new cells receive DNA that has been ...
Lauren Pecorino
core +2 more sources