Results 51 to 60 of about 342,913 (296)

The role of oxidative stress-related genes in idiopathic pulmonary fibrosis

Scientific Reports
Idiopathic pulmonary fibrosis (IPF) is an age-related interstitial lung disease of unknown cause. Oxidative stress, an imbalance between oxidants and antioxidants, is implicated in IPF pathogenesis and prognosis but needs further study.
Wenfei Zhao, Bing Bai, Hongyun Li, Yonghai Feng, Jun Sun, Yang Fang, Pengyuan Zheng, Guojun Zhang   +7 more
doaj   +1 more source

miRNAs link metabolic reprogramming to oncogenesis

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Iliopoulos, D, Hatziapostolou, M, Polytarchou, C   +2 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans

Clinical Epigenetics, 2017
Background Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection.
Hugo Sanchez, Mohammad B. Hossain, Lydia Lera, Sandra Hirsch, Cecilia Albala, Ricardo Uauy, Karin Broberg, Ana M. Ronco   +7 more
doaj   +1 more source

In vivo genome‐editing screen identifies tumor suppressor genes that cooperate with Trp53 loss during mammary tumorigenesis

Molecular Oncology, 2022
Breast cancer is a heterogeneous disease that comprises multiple histological and molecular subtypes. To gain insight into mutations that drive breast tumorigenesis, we describe a pipeline for the identification and validation of tumor suppressor genes ...
Luuk Heitink, James R. Whittle, François Vaillant, Bianca D. Capaldo, Johanna F. Dekkers, Caleb A. Dawson, Michael J. G. Milevskiy, Elliot Surgenor, Minhsuang Tsai, Huei‐Rong Chen, Michael Christie, Yunshun Chen, Gordon K. Smyth, Marco J. Herold, Andreas Strasser, Geoffrey J. Lindeman, Jane E. Visvader   +16 more
doaj   +1 more source

Functional genomics of brain development and developmentally related brain disease in "Drosophila" [PDF]

, 2004
One of the fundamental challenges in basic neuroscience is to understand the molecular genetic networks associated with building the brain. As malfunction in these genetic pathways can lead to disorders like cancer, brain development is also a crucial ...
Loop, Thomas
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Gene expression array analysis to identify candidate tumor suppressor genes in melanoma

, 2017
Melanoma is a complex multifactorial disease; therefore, a combination of various approaches is necessary to girt all aspects of its biology and identify the many different genes and factors involved in its etiology.Epigenetic regulation of tumor ...
Stark, Mitchell S., Bonazzi, Vanessa F., Mitchell S. Stark, Vanessa F. Bonazzi   +3 more
core   +1 more source

Crosstalk between c-Jun and TAp73alpha/beta contributes to the apoptosis–survival balance [PDF]

, 2011
The p53-family member p73 plays a role in various cellular signaling pathways during development and growth control and it can have tumor suppressor properties. Several isoforms of p73 exist with considerable differences in their function.
Simon J. van Heeringen, Smeenk, L., Smeenk, Leonie, Hartmann, Marianne, Eva Janssen-Megens, Lohrum, Marion, Koeppel, M., Heeringen, S.J. van, Hendrik G. Stunnenberg, Daniela Kramer, Hartmann, M., Lohrum, M., Stunnenberg, H.G., Stunnenberg, Hendrik G., Max Koeppel, Kramer, D., Leonie Smeenk, Koeppel, Max, Kramer, Daniela, Janssen-Megens, Eva, Heeringen, Simon J. van, Janssen-Megens, E.M., Marion Lohrum, Marianne Hartmann   +23 more
core   +1 more source