Analysis of retinoblastoma-associated genes using bioinformatic methods
Digital Diagnostics, 2023 BACKGROUND: Retinoblastoma is a common neoplasia that affects the visual organ in young children. The mortality rate is approximately 15%. In 91% of cases, surgery with enucleation is required, which significantly reduces the patients quality of life ...
Kirill Yu. Klimov
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A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression. [PDF]
PLoS ONE, 2016 BACKGROUND:While RB1 loss initiates retinoblastoma development, additional somatic copy number alterations (SCNAs) can drive tumor progression. Although SCNAs have been identified with good concordance between studies at a cytoband resolution, accurate ...
Irsan E Kooi +11 more
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Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors [PDF]
Frontiers in Oncology, 2019 Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
Swetha Rajasekaran +20 more
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BIRC5 drives cell-cycle dysregulation and represents a novel molecular target in retinoblastoma [PDF]
Frontiers in OncologyAims and objectivesRetinoblastoma is the most common pediatric intraocular malignancy, although it remains a rare disease overall, yet the molecular targets and therapeutic vulnerabilities sustaining its most aggressive proliferative cell states remain ...
Yingtong Chen +9 more
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BTG interacts with retinoblastoma to control cell fate in Dictyostelium. [PDF]
PLoS ONE, 2010 BACKGROUND: In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering ...
Daniele Conte +2 more
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Lancet, The, 2012 Retinoblastoma is the first tumor suppressor gene discovered ever. The discovery opened a new avenue in the field of oncology leading to the identification of 35 tumor suppressor genes, till date in our genome.
Helen Dimaras +2 more
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RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking [PDF]
Frontiers in ImmunologyPurposeRetinoblastoma is the most common intraocular cancer in infants and children, with a significant potential for metastasis. The mini-peptide ribosomal protein L41 (RPL41) has demonstrated extensive antitumor effects in vitro by promoting the ...
Ye Li +6 more
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Transcriptome profiling of uterine leiomyosarcomas identifies a leiomyoma-like expression pattern that indicates better survival [PDF]
BJC ReportsBackground Uterine leiomyosarcomas are rare and aggressive cancers with poor survival. Their non-cancerous counterparts, uterine leiomyomas, are common tumors affecting many women during reproductive years.
Sara Khamaiseh +7 more
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Genetics and Epigenetics of Human Retinoblastoma [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2015 Retinoblastoma is a pediatric tumor of the developing retina from which the genetic basis for cancer development was first described. Inactivation of both copies of the RB1 gene is the predominant initiating genetic lesion in retinoblastoma and is rate ...
Claudia A Benavente, Michael A Dyer
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Epigenetic Factors in Pathogenesis of Retinoblastoma: DNA Methylation and Histone Acetylation [PDF]
Current Issues in Molecular Biology(Background) Retinoblastoma is the most common intraocular malignancy in childhood, primarily caused by mutations in the RB1 gene. However, increasing evidence highlights the significant role of epigenetic mechanisms, particularly DNA methylation and ...
Georgios Kiosis +8 more
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